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Polymers 2018, 10(7), 768; https://doi.org/10.3390/polym10070768

Bioactive and Bioadhesive Catechol Conjugated Polymers for Tissue Regeneration

1
Institute of Polymer Science and Technology, ICTP-CSIC, Juan de la Cierva 3, 28006 Madrid, Spain
2
CIBER’s Bioengineering, Biomaterials and Nanomedicine, CIBER-BBN, Health Institute Carlos III, C/Monforte de Lemos 3-5, Pabellón 11, 28029 Madrid, Spain
*
Author to whom correspondence should be addressed.
Received: 7 June 2018 / Revised: 3 July 2018 / Accepted: 11 July 2018 / Published: 13 July 2018
(This article belongs to the Special Issue Polymers for Therapy and Diagnostics)
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Abstract

The effective treatment of chronic wounds constitutes one of the most common worldwide healthcare problem due to the presence of high levels of proteases, free radicals and exudates in the wound, which constantly activate the inflammatory system, avoiding tissue regeneration. In this study, we describe a multifunctional bioactive and resorbable membrane with in-built antioxidant agent catechol for the continuous quenching of free radicals as well as to control inflammatory response, helping to promote the wound-healing process. This natural polyphenol (catechol) is the key molecule responsible for the mechanism of adhesion of mussels providing also the functionalized polymer with bioadhesion in the moist environment of the human body. To reach that goal, synthesized statistical copolymers of N-vinylcaprolactam (V) and 2-hydroxyethyl methacrylate (H) have been conjugated with catechol bearing hydrocaffeic acid (HCA) molecules with high yields. The system has demonstrated good biocompatibility, a sustained antioxidant response, an anti-inflammatory effect, an ultraviolet (UV) screen, and bioadhesion to porcine skin, all of these been key features in the wound-healing process. Therefore, these novel mussel-inspired materials have an enormous potential for application and can act very positively, favoring and promoting the healing effect in chronic wounds. View Full-Text
Keywords: wound healing; catechol; conjugated; antioxidant; anti-inflammatory; bioadhesion; ultraviolet (UV) shielding wound healing; catechol; conjugated; antioxidant; anti-inflammatory; bioadhesion; ultraviolet (UV) shielding
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Puertas-Bartolomé, M.; Vázquez-Lasa, B.; San Román, J. Bioactive and Bioadhesive Catechol Conjugated Polymers for Tissue Regeneration. Polymers 2018, 10, 768.

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