Next Article in Journal
Multienzyme Immobilized Polymeric Membrane Reactor for the Transformation of a Lignin Model Compound
Next Article in Special Issue
Permeability of Novel Chitosan-g-Poly(Methyl Methacrylate) Amphiphilic Nanoparticles in a Model of Small Intestine In Vitro
Previous Article in Journal
Mussel-Inspired Polydopamine as a Green, Efficient, and Stable Platform to Functionalize Bamboo Fiber with Amino-Terminated Alkyl for High Performance Poly(butylene succinate) Composites
Previous Article in Special Issue
Biocompatible and Antibacterial Nitric Oxide-Releasing Pluronic F-127/Chitosan Hydrogel for Topical Applications
Article Menu
Issue 4 (April) cover image

Export Article

Open AccessReview
Polymers 2018, 10(4), 462;

Biomedical Applications of Chitosan and Its Derivative Nanoparticles

Key Laboratory of Microbiology, School of Life Science, Heilongjiang University, Harbin 150080, China
Author to whom correspondence should be addressed.
Received: 22 March 2018 / Revised: 17 April 2018 / Accepted: 17 April 2018 / Published: 23 April 2018
(This article belongs to the Special Issue Polymers for Therapy and Diagnostics)
Full-Text   |   PDF [3239 KB, uploaded 3 May 2018]   |  


Chitosan is a biodegradable natural polymer with many advantages such as nontoxicity, biocompatibility, and biodegradability. It can be applied in many fields, especially in medicine. As a delivery carrier, it has great potential and cannot be compared with other polymers. Chitosan is extremely difficult to solubilize in water, but it can be solubilized in acidic solution. Its insolubility in water is a major limitation for its use in medical applications. Chitosan derivatives can be obtained by chemical modification using such techniques as acylation, alkylation, sulfation, hydroxylation, quaternization, esterification, graft copolymerization, and etherification. Modified chitosan has chemical properties superior to unmodified chitosan. For example, nanoparticles produced from chitosan derivatives can be used to deliver drugs due to their stability and biocompatibility. This review mainly focuses on the properties of chitosan, chitosan derivatives, and the origin of chitosan-based nanoparticles. In addition, applications of chitosan-based nanoparticles in drug delivery, vaccine delivery, antimicrobial applications, and callus and tissue regeneration are also presented. In summary, nanoparticles based on chitosan have great potential for research and development of new nano vaccines and nano drugs in the future. View Full-Text
Keywords: chitosan and its derivatives; nanoparticles; delivery system; biomedical application chitosan and its derivatives; nanoparticles; delivery system; biomedical application

Graphical abstract

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

Share & Cite This Article

MDPI and ACS Style

Zhao, D.; Yu, S.; Sun, B.; Gao, S.; Guo, S.; Zhao, K. Biomedical Applications of Chitosan and Its Derivative Nanoparticles. Polymers 2018, 10, 462.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Polymers EISSN 2073-4360 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top