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Polymers 2018, 10(4), 462; https://doi.org/10.3390/polym10040462

Biomedical Applications of Chitosan and Its Derivative Nanoparticles

Key Laboratory of Microbiology, School of Life Science, Heilongjiang University, Harbin 150080, China
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Received: 22 March 2018 / Revised: 17 April 2018 / Accepted: 17 April 2018 / Published: 23 April 2018
(This article belongs to the Special Issue Polymers for Therapy and Diagnostics)
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Abstract

Chitosan is a biodegradable natural polymer with many advantages such as nontoxicity, biocompatibility, and biodegradability. It can be applied in many fields, especially in medicine. As a delivery carrier, it has great potential and cannot be compared with other polymers. Chitosan is extremely difficult to solubilize in water, but it can be solubilized in acidic solution. Its insolubility in water is a major limitation for its use in medical applications. Chitosan derivatives can be obtained by chemical modification using such techniques as acylation, alkylation, sulfation, hydroxylation, quaternization, esterification, graft copolymerization, and etherification. Modified chitosan has chemical properties superior to unmodified chitosan. For example, nanoparticles produced from chitosan derivatives can be used to deliver drugs due to their stability and biocompatibility. This review mainly focuses on the properties of chitosan, chitosan derivatives, and the origin of chitosan-based nanoparticles. In addition, applications of chitosan-based nanoparticles in drug delivery, vaccine delivery, antimicrobial applications, and callus and tissue regeneration are also presented. In summary, nanoparticles based on chitosan have great potential for research and development of new nano vaccines and nano drugs in the future. View Full-Text
Keywords: chitosan and its derivatives; nanoparticles; delivery system; biomedical application chitosan and its derivatives; nanoparticles; delivery system; biomedical application
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Zhao, D.; Yu, S.; Sun, B.; Gao, S.; Guo, S.; Zhao, K. Biomedical Applications of Chitosan and Its Derivative Nanoparticles. Polymers 2018, 10, 462.

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