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Open AccessArticle

Engineering Polyzwitterion and Polydopamine Decorated Doxorubicin-Loaded Mesoporous Silica Nanoparticles as a pH-Sensitive Drug Delivery

School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China
Department of Basic Medical Sciences, North China University of Science and Technology, Tangshan 063000, China
School of Pharmaceutical Science (Shenzhen), Sun Yat-sen University (SYSU), 135 Xingang Xi Road, Guangzhou 510275, China
Key Laboratory of Systems Bioengineering of Ministry of Education, Tianjin University, Tianjin 300072, China
Authors to whom correspondence should be addressed.
Polymers 2018, 10(3), 326;
Received: 22 January 2018 / Revised: 13 March 2018 / Accepted: 14 March 2018 / Published: 15 March 2018
(This article belongs to the Special Issue Polymer Hybrid Materials)
Multifunctional drug carriers have great applications in biomedical field. In this study, we introduced both polydopamine (PDA) and zwitterionic polymer of poly(3-(3-methacrylamidopropyl-(dimethyl)-ammonio)propane-1-sulfonate) (PSPP) onto the surface of mesoporous silica nanoparticles (MSNs) to develop a novel nanoparticle ([email protected]), which was employed as a new kind of drug carrier for the delivery of doxorubicin (DOX). The PDA coating, as a gatekeeper, could endow the drug carrier with pH-sensitive drug release performance. The outermost PSPP layer would make the drug carrier possess protein resistance performance. The chemical structure and properties were characterized by Fourier transform infrared spectroscopy (FTIR), transmission electron microscopy (TEM), dynamic light scattering (DLS) and thermogravimetric analysis (TGA). [email protected] could keep good colloidal stability within 72 h in phosphate buffered saline (PBS) and protein solutions. Meanwhile, [email protected] exhibited a high drug loading for DOX. In vitro drug release experiments suggested [email protected] exhibited pH-dependent drug release behaviors. Besides, [email protected] had no cytotoxicity to human hepatocellular carcinoma cells (HepG2 cells) even at a concentration of 125 µg/mL. More importantly, cellular uptake and in vitro anticancer activity tests suggested that [email protected] could be taken up by HepG2 cells and DOX could be successfully released and delivered into the cell nuclei. Taken together, [email protected] have great potential in the biomedical field. View Full-Text
Keywords: mesoporous silica; surface modification; zwitterionic polymer; pH-sensitivity mesoporous silica; surface modification; zwitterionic polymer; pH-sensitivity
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MDPI and ACS Style

Ji, F.; Sun, H.; Qin, Z.; Zhang, E.; Cui, J.; Wang, J.; Li, S.; Yao, F. Engineering Polyzwitterion and Polydopamine Decorated Doxorubicin-Loaded Mesoporous Silica Nanoparticles as a pH-Sensitive Drug Delivery. Polymers 2018, 10, 326.

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