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Polymers 2018, 10(2), 175; https://doi.org/10.3390/polym10020175

Formulation of Carbopol®/Poly(2-ethyl-2-oxazoline)s Mucoadhesive Tablets for Buccal Delivery of Hydrocortisone

1
Macromolecular Chemistry Group (LABQUIMAC), Department of Physical Chemistry, Faculty of Science and Technology, University of the Basque Country, UPV/EHU, Barrio Sarriena, s/n, 48940 Leioa, Spain
2
Analytical Chemistry Department, Faculty of Science and Technology, University of the Basque Country, UPV/EHU, Barrio Sarriena, s/n, 48940 Leioa, Spain
3
School of Pharmacy, University of Reading, Whiteknights, P.O. Box 224, Reading RG6 6AD, UK
*
Authors to whom correspondence should be addressed.
Received: 25 December 2017 / Revised: 29 January 2018 / Accepted: 7 February 2018 / Published: 11 February 2018
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Abstract

Poly(2-ethyl-2-oxazoline) has become an excellent alternative to the use of poly(ethylene glycol) in pharmaceutical formulations due to its valuable physicochemical and biological properties. This work presents a formulation of poorly-water soluble drug, hydrocortisone, using interpolymer complexes and physical blends of poly(2-ethyl-2-oxazoline)s and two Carbopols® (Carbopol 974 and Carbopol 971) for oromucosal administration. The swelling, hydrocortisone release and mucoadhesive properties of a series of tablet formulations obtained by combination of different Carbopols with poly(2-ethyl-2-oxazoline)s of different molecular weights have been evaluated in vitro. View Full-Text
Keywords: poly(2-ethyl-2-oxazoline); Carbopol®; mucoadhesion; interpolymer complexes poly(2-ethyl-2-oxazoline); Carbopol®; mucoadhesion; interpolymer complexes
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Ruiz-Rubio, L.; Alonso, M.L.; Pérez-Álvarez, L.; Alonso, R.M.; Vilas, J.L.; Khutoryanskiy, V.V. Formulation of Carbopol®/Poly(2-ethyl-2-oxazoline)s Mucoadhesive Tablets for Buccal Delivery of Hydrocortisone. Polymers 2018, 10, 175.

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