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Review

Solution Cocrystallization: A Scalable Approach for Cocrystal Production

Department of Chemical and Biochemical Engineering, Indian Institute of Technology Patna, Patna 801106, India
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Academic Editor: Sébastien Teychené
Crystals 2021, 11(3), 303; https://doi.org/10.3390/cryst11030303
Received: 22 February 2021 / Revised: 6 March 2021 / Accepted: 14 March 2021 / Published: 18 March 2021
(This article belongs to the Special Issue Crystal Nucleation and Growth Kinetics)
With an increasing interest in cocrystals due to various advantages, demand for large-scale cocrystallization techniques is rising. Solution cocrystallization is a solvent-based approach that utilizes several single-component crystallization concepts as well as equipment for generating cocrystals. Solution-based techniques can produce cocrystals with reasonable control on purity, size distribution, morphology, and polymorphic form. Many of them also offer a scalable solution for the industrial production of cocrystals. However, the complexity of the thermodynamic landscape and the kinetics of cocrystallization offers fresh challenges which are not encountered in single component crystallization. This review focuses on the recent developments in different solution cocrystallization techniques for the production of pharmaceutically relevant cocrystals. The review consists of two sections. The first section describes the various solution cocrystallization methods, highlighting their benefits and limitations. The second section emphasizes the challenges in developing these techniques to an industrial scale and identifies the major thrust areas where further research is required. View Full-Text
Keywords: cocrystals; solution cocrystallization; scale-up; cocrystallization kinetics; modeling; PAT tools cocrystals; solution cocrystallization; scale-up; cocrystallization kinetics; modeling; PAT tools
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MDPI and ACS Style

Pawar, N.; Saha, A.; Nandan, N.; Parambil, J.V. Solution Cocrystallization: A Scalable Approach for Cocrystal Production. Crystals 2021, 11, 303. https://doi.org/10.3390/cryst11030303

AMA Style

Pawar N, Saha A, Nandan N, Parambil JV. Solution Cocrystallization: A Scalable Approach for Cocrystal Production. Crystals. 2021; 11(3):303. https://doi.org/10.3390/cryst11030303

Chicago/Turabian Style

Pawar, Nitin, Anindita Saha, Neelesh Nandan, and Jose V. Parambil 2021. "Solution Cocrystallization: A Scalable Approach for Cocrystal Production" Crystals 11, no. 3: 303. https://doi.org/10.3390/cryst11030303

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