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Open AccessReview

Fluorescent Gold Nanoclusters for Biosensor and Bioimaging Application

by Yunlong Bai 1,2, Tong Shu 1,2,3,*, Lei Su 1,2 and Xueji Zhang 1,2,4,*
1
Research Center for Biomedical and Health Science, Anhui Science and Technology University, Fengyang 233100, China
2
Research Center for Bioengineering and Sensing Technology, School of Chemistry and Biological Engineering, University of Science and Technology Beijing, Beijing 100083, China
3
Guangdong Provincial Key Laboratory of Luminescence from Molecular Aggregates, South China University of Technology, Guangzhou 510640, China
4
School of Biomedical Engineering, Shenzhen University Health Science Center, Shenzhen 518060, Guangdong, China
*
Authors to whom correspondence should be addressed.
Crystals 2020, 10(5), 357; https://doi.org/10.3390/cryst10050357
Received: 9 April 2020 / Revised: 27 April 2020 / Accepted: 28 April 2020 / Published: 30 April 2020
(This article belongs to the Special Issue Fluorescent Complexes)
With the rapid development of materials technology, fluorescent gold nanoclusters (AuNCs) are emerging as novel functional materials for diagnostic applications including the detection of biomarkers and bioimaging due to the advantages of their ultra-small size, tunable emissions, size-dependent fluorescence and excellent biocompatibility. In this review, we introduced the synthetic methods, and physical and chemical properties of AuNCs. Subsequently, we described the AuNCs-based design strategies for the detection of biomarkers including small molecules, DNA and proteins. The applications of AuNCs for tumor imaging in vitro and in vivo were also presented. Finally, we discussed the challenges and potential solutions of AuNCs-based nanosensors. View Full-Text
Keywords: gold nanoclusters; biomarker; biosensor; bioimaging gold nanoclusters; biomarker; biosensor; bioimaging
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MDPI and ACS Style

Bai, Y.; Shu, T.; Su, L.; Zhang, X. Fluorescent Gold Nanoclusters for Biosensor and Bioimaging Application. Crystals 2020, 10, 357.

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