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Open AccessArticle

Selective Acetylation of Small Biomolecules and Their Derivatives Catalyzed by Er(OTf)3

Dipartimento di Chimica, Università della Calabria Cubo 12C, 87036 Arcavacata di Rende CS, Italy
Dipartimento di Agraria, Università Telematica San Raffaele, Roma, Via di Val Cannuta, 247, 00166 Rome, Italy
Dipartimento di Farmacia e Scienze della Salute e della Nutrizione, Edificio Polifunzionale, Università della Calabria, Arcavacata di Rende, 87030 Cosenza, Italy
Dipartimento di Scienze della Salute, Università Magna Graecia, Viale Europa, Germaneto, 88100 Catanzaro CZ, Italy
Authors to whom correspondence should be addressed.
Catalysts 2017, 7(9), 269;
Received: 21 July 2017 / Revised: 5 September 2017 / Accepted: 6 September 2017 / Published: 12 September 2017
PDF [9291 KB, uploaded 13 September 2017]


It is of great significance to develop sustainable processes of catalytic reaction. We report a selective procedure for the synthesis of acetylated bioactive compounds in water. The use of 1-acetylimidazole combined with Er(OTf)3 as a Lewis acid catalyst gives high regioselectivity and good yields for the acetylation of primary hydroxyl groups, as well as amino groups. The protection is achieved in short reaction times under microwave irradiation, and is successful even in the case of base-sensitive substrates. View Full-Text
Keywords: catalysis; acetylation; biomolecules catalysis; acetylation; biomolecules

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Nardi, M.; Gioia, M.L.D.; Costanzo, P.; Nino, A.D.; Maiuolo, L.; Oliverio, M.; Olivito, F.; Procopio, A. Selective Acetylation of Small Biomolecules and Their Derivatives Catalyzed by Er(OTf)3. Catalysts 2017, 7, 269.

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