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Open AccessArticle

Organocatalytic Asymmetric Michael Addition of Ketones to α, β-Unsaturated Nitro Compounds

1
Department of Chemistry, Research Institute for Natural Sciences, Korea University, 145 Anam-ro Seongbuk-gu, Seoul 02841, Korea
2
Department of Chemistry Education and Research Institute of Natural Science, Gyeongsang National University, Jinju 52828, Korea
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Authors to whom correspondence should be addressed.
Catalysts 2020, 10(6), 618; https://doi.org/10.3390/catal10060618
Received: 6 May 2020 / Revised: 24 May 2020 / Accepted: 28 May 2020 / Published: 2 June 2020
An organic catalyst “(R, R)-1,2-diphenylethylenediamine(DPEN) derivative’’ was devel-oped as a chiral bifunctional organocatalyst and applied for asymmetric Michael additions of aromatic ketones to trans-β-nitroalkene compounds under neutral conditions. The isopropyl-subs-tituted thiourea catalyst in neutral condition provides high chemical yield and enantioselectivities (ee) (up to 96% yield, 98% ee). View Full-Text
Keywords: organocatalyst; enantioselectivity; yield; thiourea catalyst; asymmetric organocatalyst; enantioselectivity; yield; thiourea catalyst; asymmetric
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MDPI and ACS Style

Shim, J.H.; Nam, S.H.; Kim, B.-S.; Ha, D.-C. Organocatalytic Asymmetric Michael Addition of Ketones to α, β-Unsaturated Nitro Compounds. Catalysts 2020, 10, 618.

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