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Cancers 2015, 7(1), 238-265;

Extracellular Molecules Involved in Cancer Cell Invasion

Department of Biochemistry, Hellenic Pasteur Institute, Athens 11521, Greece
Technological Educational Institute of Athens, Egaleo, Athens 12210, Greece
Author to whom correspondence should be addressed.
Academic Editor: Scott A. Weed
Received: 12 December 2014 / Revised: 30 December 2014 / Accepted: 20 January 2015 / Published: 26 January 2015
(This article belongs to the Special Issue Cancer Cell Invasion)
Full-Text   |   PDF [942 KB, uploaded 28 January 2015]   |  


Nowadays it is perfectly clear that understanding and eradicating cancer cell invasion and metastasis represent the crucial, definitive points in cancer therapeutics. During the last two decades there has been a great interest in the understanding of the extracellular molecular mechanisms involved in cancer cell invasion. In this review, we highlight the findings concerning these processes, focusing in particular on extracellular molecules, including extracellular matrix proteins and their receptors, growth factors and their receptors, matrix metalloproteinases and extracellular chaperones. We report the molecular mechanisms underlying the important contribution of this pool of molecules to the complex, multi-step phenomenon of cancer cell invasion. View Full-Text
Keywords: cell invasion; metastasis; cell surface; extracellular cell invasion; metastasis; cell surface; extracellular

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Stivarou, T.; Patsavoudi, E. Extracellular Molecules Involved in Cancer Cell Invasion. Cancers 2015, 7, 238-265.

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