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MET and Small-Cell Lung Cancer

Medical Oncology Unit 1, Medical Oncology Department, Fondazione IRCCS Istituto Nazionale Tumori, Via G. Venezian 1, 20133 Milano, Italy
Operative Unit of Pathology, Azienda Ospedaliero-Universitaria Policlinico, Via del Pozzo 71, 41124 Modena, Italy
Medical Oncology Unit, Azienda Ospedaliero-Universitaria, Viale A. Gramsci 14, 43126 Parma, Italy
Author to whom correspondence should be addressed.
Cancers 2014, 6(4), 2100-2115;
Received: 6 August 2014 / Revised: 21 September 2014 / Accepted: 22 September 2014 / Published: 13 October 2014
(This article belongs to the Special Issue MET in Cancer)
Small-cell lung cancer (SCLC) is one of the most aggressive lung tumors. The majority of patients with SCLC are diagnosed at an advanced stage. This tumor type is highly sensitive to chemo-radiation treatment, with very high response rates, but invariably relapses. At this time, treatment options are still limited and the prognosis of these patients is poor. A better knowledge of the molecular biology of SCLC allowed us to identify potential druggable targets. Among these, the MET/HGF axis seems to be one of the most aberrant signaling pathways involved in SCLC invasiveness and progression. In this review, we describe briefly all recent literature on the different molecular profiling in SCLC; in particular, we discuss the specific alterations involving c-MET gene and their implications as a potential target in SCLC. View Full-Text
Keywords: c-MET; small-cell lung cancer; mutations; c-MET signaling pathway c-MET; small-cell lung cancer; mutations; c-MET signaling pathway
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Gelsomino, F.; Rossi, G.; Tiseo, M. MET and Small-Cell Lung Cancer. Cancers 2014, 6, 2100-2115.

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