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Critical Role of Aberrant Angiogenesis in the Development of Tumor Hypoxia and Associated Radioresistance

1
Department of Radiotherapy and Radiation Oncology, Klinikum rechts der Isar, Technische Universität München, Ismaninger Straße 22, 81675 Munich, Germany
2
Clinical Cooperation Group "Innate Immunity in Tumor Biology", Helmholtz Zentrum München (HMGU), Ingolstädter Landstraße 1, 85764 Neuherberg, Germany
3
GmbH, Munich, Ismaningerstr. 22, 81675 Munich, Germany
*
Author to whom correspondence should be addressed.
Cancers 2014, 6(2), 813-828; https://doi.org/10.3390/cancers6020813
Received: 7 February 2014 / Revised: 18 March 2014 / Accepted: 21 March 2014 / Published: 8 April 2014
(This article belongs to the Special Issue Tumour Angiogenesis)
Newly formed microvessels in most solid tumors show an abnormal morphology and thus do not fulfil the metabolic demands of the growing tumor mass. Due to the chaotic and heterogeneous tumor microcirculation, a hostile tumor microenvironment develops, that is characterized inter alia by local hypoxia, which in turn can stimulate the HIF-system. The latter can lead to tumor progression and may be involved in hypoxia-mediated radioresistance of tumor cells. Herein, cellular and molecular mechanisms in tumor angiogenesis are discussed that, among others, might impact hypoxia-related radioresistance. View Full-Text
Keywords: tumor angiogenesis; tumor microcirculation; tumor hypoxia; hypoxia-inducible factor (HIF); radioresistance; hypoxia modifiers tumor angiogenesis; tumor microcirculation; tumor hypoxia; hypoxia-inducible factor (HIF); radioresistance; hypoxia modifiers
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Multhoff, G.; Radons, J.; Vaupel, P. Critical Role of Aberrant Angiogenesis in the Development of Tumor Hypoxia and Associated Radioresistance. Cancers 2014, 6, 813-828.

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