Next Article in Journal
Surgical Treatment of Intra-Abdominal Desmoid Tumors Resulting In Short Bowel Syndrome
Next Article in Special Issue
Diagnosis and Treatment of Gastrinomas in Multiple Endocrine Neoplasia Type 1 (MEN-1)
Previous Article in Journal
Tertiary Intratumor Lymphoid Tissue in Colo-Rectal Cancer
Review

Mixed Adenoneuroendocrine Carcinomas (MANECs) of the Gastrointestinal Tract: An Update

1
Department of Pathology, Ospedale di Circolo, viale Borri 57, 21100 Varese, Italy
2
Department of Surgical and Morphological Sciences, University of Insubria, via O. Rossi 9, 21100 Varese, Italy
*
Author to whom correspondence should be addressed.
Cancers 2012, 4(1), 11-30; https://doi.org/10.3390/cancers4010011
Received: 2 December 2011 / Revised: 7 January 2012 / Accepted: 12 January 2012 / Published: 16 January 2012
(This article belongs to the Special Issue Neuroendocrine Tumors)
The systematic application of immunohistochemical techniques to the study of tumors has led to the recognition that neuroendocrine cells occur rather frequently in exocrine neoplasms of the gut. It is now well known that there is a wide spectrum of combinations of exocrine and neuroendocrine components, ranging from adenomas or carcinomas with interspersed neuroendocrine cells at one extreme to classical neuroendocrine tumors with a focal exocrine component at the other. In addition, both exocrine and neuroendocrine components can have different morphological features ranging, for the former, from adenomas to adenocarcinomas with different degrees of differentiation and, for the latter, from well differentiated to poorly differentiated neuroendocrine tumors. However, although this range of combinations of neuroendocrine and exocrine components is frequently observed in routine practice, mixed exocrine-neuroendocrine carcinomas, now renamed as mixed adenoneuroendocrine carcinomas (MANECs), are rare; these are, by definition, neoplasms in which each component represents at least 30% of the lesion. Gastrointestinal MANECs can be stratified in different prognostic categories according to the grade of malignancy of each component. The present paper is an overview of the main clinicopathological, morphological, immunohistochemical and molecular features of this specific rare tumor type. View Full-Text
Keywords: adenoneuroendocrine carcinoma; mixed exocrine-neuroendocrine carcinoma; gut adenoneuroendocrine carcinoma; mixed exocrine-neuroendocrine carcinoma; gut
Show Figures

Figure 1

MDPI and ACS Style

La Rosa, S.; Marando, A.; Sessa, F.; Capella, C. Mixed Adenoneuroendocrine Carcinomas (MANECs) of the Gastrointestinal Tract: An Update. Cancers 2012, 4, 11-30. https://doi.org/10.3390/cancers4010011

AMA Style

La Rosa S, Marando A, Sessa F, Capella C. Mixed Adenoneuroendocrine Carcinomas (MANECs) of the Gastrointestinal Tract: An Update. Cancers. 2012; 4(1):11-30. https://doi.org/10.3390/cancers4010011

Chicago/Turabian Style

La Rosa, Stefano, Alessandro Marando, Fausto Sessa, and Carlo Capella. 2012. "Mixed Adenoneuroendocrine Carcinomas (MANECs) of the Gastrointestinal Tract: An Update" Cancers 4, no. 1: 11-30. https://doi.org/10.3390/cancers4010011

Find Other Styles

Article Access Map by Country/Region

1
Only visits after 24 November 2015 are recorded.
Back to TopTop