Next Article in Journal
Prevention of Prostate Cancer with Oleanane Synthetic Triterpenoid CDDO-Me in the TRAMP Mouse Model of Prostate Cancer
Next Article in Special Issue
Epigenetics, Nervous System Tumors, and Cancer Stem Cells
Previous Article in Journal
Assessment of the Evolution of Cancer Treatment Therapies
Previous Article in Special Issue
Clinical Trial Design for Testing the Stem Cell Model for the Prevention and Treatment of Cancer

Therapeutic Approaches to Target Cancer Stem Cells

Department of Systems Biology, Center of Molecular Immunology, 216 Street, PO Box 16040, Atabey, Havana 11600, Cuba
Author to whom correspondence should be addressed.
Cancers 2011, 3(3), 3331-3352;
Received: 8 May 2011 / Revised: 27 July 2011 / Accepted: 7 August 2011 / Published: 15 August 2011
(This article belongs to the Special Issue Cancer Stem Cells)
The clinical relevance of cancer stem cells (CSC) remains a major challenge for current cancer therapies, but preliminary findings indicate that specific targeting may be possible. Recent studies have shown that these tumor subpopulations promote tumor angiogenesis through the increased production of VEGF, whereas the VEGF neutralizing antibody bevacizumab specifically inhibits CSC growth. Moreover, nimotuzumab, a monoclonal antibody against the epidermal growth factor receptor (EGFR) with a potent antiangiogenic activity, has been shown by our group to reduce the frequency of CSC-like subpopulations in mouse models of brain tumors when combined with ionizing radiation. These studies and subsequent reports from other groups support the relevance of approaches based on molecular-targeted therapies to selectively attack CSC. This review discusses the relevance of targeting both the EGFR and angiogenic pathways as valid approaches to this aim. We discuss the relevance of identifying better molecular markers to develop drug screening strategies that selectively target CSC. View Full-Text
Keywords: CSC; CD133; angiogenesis; EGFR CSC; CD133; angiogenesis; EGFR
MDPI and ACS Style

Diaz, A.; Leon, K. Therapeutic Approaches to Target Cancer Stem Cells. Cancers 2011, 3, 3331-3352.

AMA Style

Diaz A, Leon K. Therapeutic Approaches to Target Cancer Stem Cells. Cancers. 2011; 3(3):3331-3352.

Chicago/Turabian Style

Diaz, Arlhee, and Kalet Leon. 2011. "Therapeutic Approaches to Target Cancer Stem Cells" Cancers 3, no. 3: 3331-3352.

Find Other Styles

Article Access Map by Country/Region

Only visits after 24 November 2015 are recorded.
Back to TopTop