Next Article in Journal
Therapeutic Response in Patients with Advanced Malignancies Treated with Combined Dendritic Cell–Activated T Cell Based Immunotherapy and Intensity–Modulated Radiotherapy
Next Article in Special Issue
Targeted Therapy for Biliary Tract Cancer
Previous Article in Journal
Harnessing Dendritic Cells for Tumor Antigen Presentation
Previous Article in Special Issue
Inferences for the Lead Time in Breast Cancer Screening Trials under a Stable Disease Model
Open AccessReview

Cell Autonomous and Non-Autonomous Functions of IKKβ and NF-κB during the Pathogenesis of Gastrointestinal Tumors

Institute of Molecular Immunology, Klinikum rechts der Isar, Technical University Munich, Ismaninger Str. 22, Munich 81675, Germany
Author to whom correspondence should be addressed.
Cancers 2011, 3(2), 2214-2222;
Received: 6 February 2011 / Revised: 4 April 2011 / Accepted: 14 April 2011 / Published: 28 April 2011
(This article belongs to the Special Issue Cancer Diagnosis and Targeted Therapy)
Genetic studies describing a link between cancer and inflammation have increased recently. Activation of the transcription factor nuclear factor-κB (NF-κB) and its effector pathways has been proposed to be the missing link between these two processes. NF-κB is persistently activated in several types of tumors. However, NF-κB has a distinct role in cancer cells and in inflammatory cells. While in tumor cells NF-κB controls cell survival, in inflammatory cells NF-κB activates genes that encode pro-inflammatory cytokines which further act in a paracrine manner within the tumor microenvironment to contribute to tumorigenesis. Inactivation of NF-κB can also reduce chemoresistance and radioresistance of cancer cells. Therefore, specific NF-κB inhibition in combination with cytotoxic drugs and/or irradiation represents a very promising strategy for cancer therapy. View Full-Text
Keywords: NF-κB; inflammation; gastrointestinal cancer NF-κB; inflammation; gastrointestinal cancer
Show Figures

Graphical abstract

MDPI and ACS Style

Fang, H.-Y.; Greten, F.R. Cell Autonomous and Non-Autonomous Functions of IKKβ and NF-κB during the Pathogenesis of Gastrointestinal Tumors. Cancers 2011, 3, 2214-2222.

Show more citation formats Show less citations formats

Article Access Map by Country/Region

Only visits after 24 November 2015 are recorded.
Search more from Scilit
Back to TopTop