Different Serotonergic Expression in Nevomelanocytic Tumors
Abstract
:1. Introduction
2. Materials and methods
2.1. Tissue Specimens
2.2. Immunohistochemical Procedure
2.3. Double Staining
2.4. Microscopy
2.5. Statistics
3. Results
3.1. General Findings
3.2. Migration of Cells into the Suprabasal Epidermis
3.3. Expression in the Junction Area between Epidermis and Dermis
3.4. The Strength of the Signal from Tumor Cells in the Dermis
3.5. Vessel Immunoreactivity
Cells in the suprabasal epidermis | Junction area | Dermis Signal strength in tumour cells | Vessels | i SERT | i 5-HT1A | ||
---|---|---|---|---|---|---|---|
BCN | 5-HT | 0 | 1.0 ± 0.7 | 1.0 ± 0 | 0 ± 0 | ||
DN | 5-HT | 0.6 ± 0.7 | 0.8 ± 0.8 | 1.1 ± 0.3 | 0.1 ±0.3 | ||
SSM | 5-HT | 1.5 ± 0.5 | 0.5 ± 0.5 | 1.3 ± 0.6 | 0.2 ± 0.4 |
3.6. Infiltration of SERT- and 5-HT1AR-Immunoreactive Cells into the Dermal Region of the Tumor
4. Discussion
5. Conclusion
Acknowledgements
References
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Naimi-Akbar, C.; Ritter, M.; Demel, S.; El-Nour, H.; Hedblad, M.-A.; Azmitia, E.C.; Nordlind, K. Different Serotonergic Expression in Nevomelanocytic Tumors. Cancers 2010, 2, 1166-1177. https://doi.org/10.3390/cancers2021166
Naimi-Akbar C, Ritter M, Demel S, El-Nour H, Hedblad M-A, Azmitia EC, Nordlind K. Different Serotonergic Expression in Nevomelanocytic Tumors. Cancers. 2010; 2(2):1166-1177. https://doi.org/10.3390/cancers2021166
Chicago/Turabian StyleNaimi-Akbar, Clara, Markus Ritter, Sasika Demel, Husameldin El-Nour, Mari-Anne Hedblad, Efrain C. Azmitia, and Klas Nordlind. 2010. "Different Serotonergic Expression in Nevomelanocytic Tumors" Cancers 2, no. 2: 1166-1177. https://doi.org/10.3390/cancers2021166