Arterial Resections in Pancreatic Cancer—An Updated Systematic Review and Meta-Analysis
Simple Summary
Abstract
1. Introduction
2. Materials and Methods
2.1. Search Strategy
2.2. Eligibility Assessment
2.3. Study Selection
2.4. Quality Assessment
2.5. Statistical Analysis
3. Results
First Author | Year | Study Type | Total | Country | Sex: M/F | Mean Age | Types of Operation (Surgery) | Type of Surgical Approach | Complications | NOS |
---|---|---|---|---|---|---|---|---|---|---|
Loos [16] | 2024 | R | 2135 | Germany | 659/793 | 61.5/62.3 | DP (2135, 100%) | Open/LAP/ROB | POPF/DGE/NAT/PPH/CDC/LOS | 7 |
Asano [17] | 2018 | R | 51 | Japan | 27/24 | 73/73 | PD (51, 100%) | NR | BL/CDC/LOS | 4 |
Yang [11] | 2019 | R | 56 | China | 32/24 | 63.5/63.8 | PD (44, 78.5%), TP (12, 22.2%) | Open/LAP/ROB | POPF/DGE/BL/NAT/PPH/CDC/LOS/R0 | 8 |
Li [15] | 2021 | R | 92 | China | 54/38 | 63.1/61.5 | DP (92, 100%) | NR | POPF/DGE/BL/NAT/PPH/CDC/LOS | 9 |
Malinka [13] | 2020 | R | 40 | Germany | 22/18 | 65.05/60.75 | DP (40, 100%) | Open/LAP/ROB | POPF/DGE/NAT/PPH/CDC/LOS | 8 |
Storkholm [14] | 2020 | P | 89 | Denmark | 50/39 | 62.3/58.3 | DP (89, 100%) | Open/LAP/ROB | POPF/DGE/BL/NAT/PPH/CDC/LOS/R0 | 6 |
Zettervall [12] | 2019 | R | 3002 | USA | 1420/1198 | 64/63 | PD (3002, 100%) | Open/LAP/ROB | POPF/DGE | 6 |
3.1. Morbidity
3.2. Mortality
3.3. Survival
3.4. Blood Loss
3.5. Clavien–Dindo Classification (CDC) ≥ 3
3.6. Hospital Length of Stay (LOS)
3.7. Neoadjuvant Chemotherapy Treatment (NAT)
3.8. Delayed Emptying (DGE)
3.9. Post-Pancreatectomy Hemorrhage (PPH)
3.10. Post-Operative Pancreatic Fistula (POPF)
3.11. R0 Resection
3.12. Heterogeneity and Publication Bias
4. Discussion
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Conflicts of Interest
References
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Author | Surgery Type | ||||||||
---|---|---|---|---|---|---|---|---|---|
Concomitant Arterial Resection | Non-Arterial Standard Resections | p-Value | |||||||
Median OS (Months) | 1-Year OS (%) | 2-Year OS (%) | 3-Year OS (%) | Median OS (Months) | 1-Year OS (%) | 2-Year OS (%) | 3-Year OS (%) | ||
Yang et al. | NS | 81.8 | 63.6 | 42.4 | NS | 74 | 40 | 38 | <0.001 |
Li et al. | 27.4 | 85 | 45 | 30 | 32.6 | 94.3 | 67.1 | 51.4 | <0.001 |
Malinka et al. | NS | 88 | 78 | 78 | NS | 90 | 60 | 60 | <0.001 |
Mean (1-, 2-, 3-year OS) | 84.9 | 62.2 | 50.1 | 86.1 | 55.7 | 49.8 |
Variables | p | Mean Difference | SE Difference | Lower | Upper |
---|---|---|---|---|---|
1-year survival | 0.836 | 1.167 | 4.954 | −22.482 | 20.148 |
2-year survival | 0.696 | 6.500 | 14.391 | −55.420 | 68.420 |
3-year survival | 0.980 | 0.333 | 11.554 | −49.380 | 50.047 |
LOS | 0.874 | 0.383 | 2.289 | −0.736 | 0.866 |
Blood loss (mL) | 0.709 | 32.683 | 79.564 | −285.890 | 220.525 |
CDC ≥ 3 | 0.738 | 2.600 | 7.360 | −21.520 | 16.320 |
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Noel, C.; Azeez, A.; Du Preez, A.; Noel, K. Arterial Resections in Pancreatic Cancer—An Updated Systematic Review and Meta-Analysis. Cancers 2025, 17, 1540. https://doi.org/10.3390/cancers17091540
Noel C, Azeez A, Du Preez A, Noel K. Arterial Resections in Pancreatic Cancer—An Updated Systematic Review and Meta-Analysis. Cancers. 2025; 17(9):1540. https://doi.org/10.3390/cancers17091540
Chicago/Turabian StyleNoel, Colin, Adeboye Azeez, Annamarie Du Preez, and Kiera Noel. 2025. "Arterial Resections in Pancreatic Cancer—An Updated Systematic Review and Meta-Analysis" Cancers 17, no. 9: 1540. https://doi.org/10.3390/cancers17091540
APA StyleNoel, C., Azeez, A., Du Preez, A., & Noel, K. (2025). Arterial Resections in Pancreatic Cancer—An Updated Systematic Review and Meta-Analysis. Cancers, 17(9), 1540. https://doi.org/10.3390/cancers17091540