Management of Cutaneous Squamous Cell Carcinoma of the Scalp in Kidney Transplant Recipients
Simple Summary
Abstract
1. Introduction
2. Materials and Methods
2.1. Surgical Techniques
2.2. Statistical Analysis
3. Results
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
Abbreviations
BCC | Basal Cell Carcinoma |
BWH | Brigham and women’s hospital |
CNI | Calcineurin inhibitor |
CTS | Computer Tomography Scan |
cSCC | cutaneous Squamous Cell Carcinoma |
ICIs | Immune Checkpoint Inhibitors |
IS | Immunosuppressive |
KTRs | Kidney Transplant Recipients |
MMF | Mycophenolate Mofetil |
mTORi | mammalian target of rapamycin inhibitor |
NMSC | Non Melanoma skin cancer |
References
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Variable | Patients (N = 7) |
---|---|
Age, years, median (range) | 67.86 (59–75) |
Male sex, n (%) | 6 (85.7) |
Caucasian ethnicity | 7 (100) |
Original Kidney disease, n (%) | |
Diabetes mellitus type II | 1 (14.3) |
Glomerulonephritis | 2 (28.6) |
ADPKD | 1 (14.3) |
Unknown disease | 3 (42.9) |
Pre-transplant malignancies, n (%) | |
Previous cSCC | 1 (14.3) |
None | 6 (85.7) |
Comorbidities, n (%) | |
Diabetes mellitus type II | 1 (14.3) |
Arterial hypertension | 7 (100) |
Duration of dialysis treatment prior to transplantation, months, mean (range) | 68 (17–96) |
Time since kidney transplant, years, median (range) | 11 (2–20) |
Immunosuppressive (IS) regimen before enrollment, n (%) | |
Tacrolimus | 7 (100) |
Everolimus | 2 (28.6) |
MMF | 5 (71.4) |
Prednisone | 7 (100) |
Induction immunosuppression, n (%) | |
Methylprednisolone 500 mg and Basiliximab 20 mg e.v. | 7 (100) |
Immunosuppressive (IS) regimen after surgery, n (%) | |
Tacrolimus | 7 (100) |
Everolimus | 7 (100) |
MMF | 0 (0) |
Prednisone | 7 (100) |
Histological type, n (%) | |
Cutaneous Squamous cell carcinoma | 7 (100) |
Tumor stage 1, n (%) | |
pT1 | 3 (42.9) |
pT2 | 1 (14.3) |
pT3 | 3 (42.9) |
pT4 | 0 |
Nodal stage 2, n (%) | |
N0 | 7 (100%) |
Metastatic disease 2, n (%) | |
M0 | 7 (100%) |
BWH tumor classification, n (%) | |
T1 0 Hight-risk factors 4 | 1 (14.3%) |
T2 a 1 Hight-risk factors | 5 (71.4%) |
T2 b 2−3 Hight-risk factors | 1 (14.3%) |
T3 4 Hight-risk factors or bone invasion | 0 |
Stage 3, n (%) | |
Stage I | 3 (42.86%) |
Stage II | 1 (14.3%) |
Stage III | 3 (42.86%) |
Stage IVA-IVB | 0 |
Relapse or new scalp tumours, n (%) | 3 (42.86%) |
Adjuvant radiation, n (%) | 1 (14.3%) |
Recurrence (n = 2) | No Recurrence (n = 5) | p-Value | |
---|---|---|---|
Age ≥ 67 years-old | 1.000 * | ||
Yes | 1 (50) | 3 (60) | |
No | 1 (50) | 2 (40) | |
Male sex, n (%) | 2 (100) | 4 (80) | 1.000 * |
Time since kidney transplant ≥ 12 years | 1.000 * | ||
Yes | 1 (50) | 3 (60) | |
No | 1 (50) | 2 (40) | |
Tumor stage, n (%) | 0.600 * | ||
pT1 | 0 | 2 (50) | |
pT2 | 0 | 1 (25) | |
pT3 | 2 (100) | 1 (25) | |
Immunosuppressive regimen witheverolimus before enrollment | 1/1 | 1/4 | 1.000 * |
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Romano, L.; Caponio, C.; Vistoli, F.; Lupi, E.; Fargnoli, M.C.; Esposito, M.; Lancione, L.; Bellobono, M.; Hassan, T.; Iacobelli, E.; et al. Management of Cutaneous Squamous Cell Carcinoma of the Scalp in Kidney Transplant Recipients. Cancers 2025, 17, 1113. https://doi.org/10.3390/cancers17071113
Romano L, Caponio C, Vistoli F, Lupi E, Fargnoli MC, Esposito M, Lancione L, Bellobono M, Hassan T, Iacobelli E, et al. Management of Cutaneous Squamous Cell Carcinoma of the Scalp in Kidney Transplant Recipients. Cancers. 2025; 17(7):1113. https://doi.org/10.3390/cancers17071113
Chicago/Turabian StyleRomano, Lucia, Chiara Caponio, Fabio Vistoli, Ettore Lupi, Maria Concetta Fargnoli, Maria Esposito, Laura Lancione, Manuela Bellobono, Tarek Hassan, Elisabetta Iacobelli, and et al. 2025. "Management of Cutaneous Squamous Cell Carcinoma of the Scalp in Kidney Transplant Recipients" Cancers 17, no. 7: 1113. https://doi.org/10.3390/cancers17071113
APA StyleRomano, L., Caponio, C., Vistoli, F., Lupi, E., Fargnoli, M. C., Esposito, M., Lancione, L., Bellobono, M., Hassan, T., Iacobelli, E., Semproni, L., & Panarese, A. (2025). Management of Cutaneous Squamous Cell Carcinoma of the Scalp in Kidney Transplant Recipients. Cancers, 17(7), 1113. https://doi.org/10.3390/cancers17071113