CT-Guided vs. Navigational Bronchoscopic Biopsies for Solitary Pulmonary Nodules: A Single-Institution Retrospective Comparison
Abstract
:Simple Summary
Abstract
1. Introduction
2. Materials and Methods
3. Statistical Analysis
4. Results
4.1. Study Sample
4.2. Procedure
4.3. Histopathology
5. Discussion
6. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
Glossary of Abbreviations
References
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TTNA | ENB | Probability (p) | ||
---|---|---|---|---|
N (%) | 900 (89.5) | 106 (10.5) | ------------------ | |
Female sex (%) | 504 (56.0) | 56 (52.8) | 0534 | |
Mean age (years) ± SD | 67.2 ± 11.2 | 68.3 ± 9.2 | 0.250 | |
Diameter (mm) | Mean ± SD | 22.83 ± 15.34 | 17.03 ± 9.20 | <0.001 |
Nodule diameter ≥ 2 cm n (%) | 499 (55.9) | 39 (38.2) | 0.001 | |
SUV max | Mean ± SD | 6.97 ± 9.64 | 5.90 ± 10.33 | 0.314 |
Nodule SUV max ≥ 2.5 n (%) | 629 (70.0) | 60 (63.8) | 0.213 | |
Nodule location n (%) | LLL | 187 (20.8) | 10 (9.4) | 0.005 |
Lingula | 16 (1.8) | 5 (4.7) | 0.061 | |
LUL | 209 (23.2) | 32 (30.2) | 0.112 | |
RLL | 172 (19.1) | 20 (18.9) | 0.952 | |
RML | 44 (4.9) | 9 (8.5) | 0.116 | |
RUL | 272 (30.2) | 30 (28.3) | 0.683 |
TTNA | ENB | Probability (p) | |||
---|---|---|---|---|---|
Anesthesia n (%) | Local | 727 (99.2) | 0 (0.0) | <0.001 | |
Sedation | 6 (0.8) | 84 (84.8) | |||
General | 0 (0.0) | 14 (15.2) | |||
Use of fluoroscopy n (%) | --------- | 65 (61.3) | --------- | ||
Use of ROSE n (%) | --------- | 0 (0.0) | --------- | ||
Mean number of biopsies (± SD) | --------- | 5.35 (±2.62) | --------- | ||
Number of patients with complications n (%) | 477 (53.0) | 20 (18.9) | <0.001 | ||
Clavien-Dindo classification per patient with complications n (%) | Grade 1 | 403 (84.5) | 15 (75.0) | 0.264 | |
Grade 2 | 0 (0.0) | 3 (15.0) | |||
Grade 3a | 74 (15.5) | 0 (0.0) | |||
Grade 4a | 0 (0.0) | 1 (5.0) | |||
Grade 5 | 0 (0.0) | 1 (5.0) | |||
Complication types n (%) Percentages represent % of complications from total complications | Air leak | 415 (87.0) | 1 (4.0) | <0.001 | |
Pneumothorax | 411 (86) | 1 (4.0) | <0.001 | ||
Bleeding | 111 (23.3) | 7 (28.0) | 0.227 | ||
Other | Total | 1 (0.2) | 17 (68.0) | <0.001 | |
Cough | 1 (0.2) | 11 (44.0) | --------- | ||
Bradycardia | 1 (0.2) | 0 (0.0) | --------- | ||
Desaturation | 0 (0.0) | 6 (24.0) | --------- | ||
Intervention required per patient n (%) | Total | 82 (17.2) | 6 (30.0) | <0.001 | |
Chest tube | 74 (90.2) | 0 (0.0) | --------- | ||
Aspiration | 8 (9.8) | 1 (16.7) | --------- | ||
Other | Total | 0 (0.0) | 5 (83.3) | --------- | |
Oxygen | 0 (0.0) | 3 (50.0) | --------- | ||
Naloxone | 0 (0.0) | 1 (16.7) | --------- | ||
Advanced cardiovascular life support (ACLS) | 0 (0.0) | 1 (16.7) | --------- |
Sensitivity (%) | Specificity (%) | Positive Predictive Value (%) | Negative Predictive Value (%) | Accuracy (%) | ||
---|---|---|---|---|---|---|
CT-guided TTNA | <2 cm | 63.0 | 75.0 | 95.4 | 19.6 | 64.3 |
≥2 cm | 87.4 | 46.2 | 94.7 | 25.0 | 84.0 | |
Overall | 77.5 | 61.5 | 95.0 | 22.5 | 75.9 | |
ENB | <2 cm | 34.4 | 100.0 | 100.0 | 40.0 | 54.3 |
≥2 cm | 56.3 | 100.0 | 100.0 | 41.7 | 66.7 | |
Overall | 40.0 | 100.0 | 100.0 | 40.0 | 57.1 |
CT Guided TTNA | ENB | Probability (p) | ||
---|---|---|---|---|
Pathology | Negative | 180 (20.0) | 58 (54.7) | <0.001 |
Positive | 624 (69.3) | 47 (44.3) | ||
Inadequate specimen | 96 (10.7) | 1 (0.9) | ||
Other | 120 (19.2) | 9 (19.1) | ||
Sensitivity for cancer patients | 80.3 | 39.5 | ------------------ |
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Chaudry, F.A.; Thivierge-Southidara, M.; Molina, J.C.; Farooqui, S.M.; Hussain, S.T.; Libermen, M. CT-Guided vs. Navigational Bronchoscopic Biopsies for Solitary Pulmonary Nodules: A Single-Institution Retrospective Comparison. Cancers 2023, 15, 5258. https://doi.org/10.3390/cancers15215258
Chaudry FA, Thivierge-Southidara M, Molina JC, Farooqui SM, Hussain ST, Libermen M. CT-Guided vs. Navigational Bronchoscopic Biopsies for Solitary Pulmonary Nodules: A Single-Institution Retrospective Comparison. Cancers. 2023; 15(21):5258. https://doi.org/10.3390/cancers15215258
Chicago/Turabian StyleChaudry, Fawad Aleem, Maureen Thivierge-Southidara, Juan Carlos Molina, Samid M. Farooqui, Syed Talal Hussain, and Moishe Libermen. 2023. "CT-Guided vs. Navigational Bronchoscopic Biopsies for Solitary Pulmonary Nodules: A Single-Institution Retrospective Comparison" Cancers 15, no. 21: 5258. https://doi.org/10.3390/cancers15215258
APA StyleChaudry, F. A., Thivierge-Southidara, M., Molina, J. C., Farooqui, S. M., Hussain, S. T., & Libermen, M. (2023). CT-Guided vs. Navigational Bronchoscopic Biopsies for Solitary Pulmonary Nodules: A Single-Institution Retrospective Comparison. Cancers, 15(21), 5258. https://doi.org/10.3390/cancers15215258