Emerging Canonical and Non-Canonical Roles of Granzyme B in Health and Disease
Abstract
:Simple Summary
Abstract
1. Introduction
2. Canonical Roles of Granzyme B
2.1. Granzyme B Regulation in CTL and NK Cells
2.2. Regulating Self-Inflicted Damage
2.3. Transcriptional Regulation
2.4. Translational Regulation
3. Non-Lymphocytic Granzyme B Production
3.1. Mast Cells
3.2. Myeloid Derived Suppressor Cells
3.3. Signaling Mechanisms for Granzyme B Production in Non-Lymphocytic Cells
4. Non-Canonical Roles of Granzyme B
4.1. Role of Granzyme B in Inhibiting Infectious Diseases
4.2. Cytotoxicity towards Other Immune Cells
4.3. Cell Type Differentiation
4.4. Granzyme B Expression in Cancer
4.5. Extracellular Matrix Remodeling
5. Concluding Remarks
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
References
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Tibbs, E.; Cao, X. Emerging Canonical and Non-Canonical Roles of Granzyme B in Health and Disease. Cancers 2022, 14, 1436. https://doi.org/10.3390/cancers14061436
Tibbs E, Cao X. Emerging Canonical and Non-Canonical Roles of Granzyme B in Health and Disease. Cancers. 2022; 14(6):1436. https://doi.org/10.3390/cancers14061436
Chicago/Turabian StyleTibbs, Ellis, and Xuefang Cao. 2022. "Emerging Canonical and Non-Canonical Roles of Granzyme B in Health and Disease" Cancers 14, no. 6: 1436. https://doi.org/10.3390/cancers14061436