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Article

Association of Low-Grade Glioma Diagnosis and Management Approach with Mental Health Disorders: A MarketScan Analysis 2005–2014

1
Penn State College of Medicine, Hershey, PA 17033, USA
2
Department of Public Health Sciences, Penn State College of Medicine, Hershey, PA 17033, USA
3
Department of Neurosurgery, Penn State College of Medicine, Hershey, PA 17033, USA
4
Centre for Minimally Invasive Neurosurgery, Prince of Wales Private Hospital, Randwick, NSW 2031, Australia
5
Penn State Cancer Institute, Hershey, PA 17033, USA
*
Author to whom correspondence should be addressed.
Academic Editor: Nils Ole Schmidt
Cancers 2022, 14(6), 1376; https://doi.org/10.3390/cancers14061376
Received: 10 January 2022 / Revised: 27 February 2022 / Accepted: 4 March 2022 / Published: 8 March 2022
(This article belongs to the Special Issue Functional Neuro-Oncology)
Low-grade gliomas (LGGs) comprise 13–16% of glial tumors. As survival for LGG patients has been improving, it is important to consider the effects of diagnosis and treatment on mental health. The aims of this retrospective cohort study were to determine the incidence, prevalence, and risk factors of mental health disorders (MHD) in LGG patients. In our analysis including 20,432 LGG patients, we identified an MHD prevalence of 60.9%. Of those with no history of prior MHD, 16.9% of LGG patients developed a new onset of MHD within 12 months of LGG diagnosis. Risk factors included female gender, ages 35–54, presence of seizures, and first-line surgical treatment. Therefore, proactive surveillance and counseling surrounding MHDs are recommended among LGG patients. Impact of surgery on brain networks affecting mood should also be considered.
Low-grade gliomas (LGGs) comprise 13–16% of glial tumors. As survival for LGG patients has been gradually improving, it is essential that the effects of diagnosis and disease progression on mental health be considered. This retrospective cohort study queried the IBM Watson Health MarketScan® Database to describe the incidence and prevalence of mental health disorders (MHDs) among LGG patients and identify associated risk factors. Among the 20,432 LGG patients identified, 12,436 (60.9%) had at least one MHD. Of those who never had a prior MHD, as documented in the claims record, 1915 (16.7%) had their first, newly diagnosed MHD within 12 months after LGG diagnosis. Patients who were female (odds ratio (OR), 1.14, 95% confidence intervals (CI), 1.03–1.26), aged 35–44 (OR, 1.20, 95% CI, 1.03–1.39), and experienced glioma-related seizures (OR, 2.19, 95% CI, 1.95–2.47) were significantly associated with MHD incidence. Patients who underwent resection (OR, 2.58, 95% CI, 2.19–3.04) or biopsy (OR, 2.17, 95% CI, 1.68–2.79) were also more likely to develop a MHD compared to patients who did not undergo a first-line surgical treatment. These data support the need for active surveillance, proactive counseling, and management of MHDs in patients with LGG. Impact of surgery on brain networks affecting mood should also be considered. View Full-Text
Keywords: glioma; low-grade; mental health disorder; quality of life; connectomics; resection; biopsy glioma; low-grade; mental health disorder; quality of life; connectomics; resection; biopsy
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MDPI and ACS Style

Bhanja, D.; Ba, D.; Tuohy, K.; Wilding, H.; Trifoi, M.; Padmanaban, V.; Liu, G.; Sughrue, M.; Zacharia, B.; Leslie, D.; Mansouri, A. Association of Low-Grade Glioma Diagnosis and Management Approach with Mental Health Disorders: A MarketScan Analysis 2005–2014. Cancers 2022, 14, 1376. https://doi.org/10.3390/cancers14061376

AMA Style

Bhanja D, Ba D, Tuohy K, Wilding H, Trifoi M, Padmanaban V, Liu G, Sughrue M, Zacharia B, Leslie D, Mansouri A. Association of Low-Grade Glioma Diagnosis and Management Approach with Mental Health Disorders: A MarketScan Analysis 2005–2014. Cancers. 2022; 14(6):1376. https://doi.org/10.3390/cancers14061376

Chicago/Turabian Style

Bhanja, Debarati, Djibril Ba, Kyle Tuohy, Hannah Wilding, Mara Trifoi, Varun Padmanaban, Guodong Liu, Michael Sughrue, Brad Zacharia, Douglas Leslie, and Alireza Mansouri. 2022. "Association of Low-Grade Glioma Diagnosis and Management Approach with Mental Health Disorders: A MarketScan Analysis 2005–2014" Cancers 14, no. 6: 1376. https://doi.org/10.3390/cancers14061376

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