Next Article in Journal
Tumor Signature Analysis Implicates Hereditary Cancer Genes in Endometrial Cancer Development
Previous Article in Journal
Digital Gene Expression Analysis of Epithelioid and Sarcomatoid Mesothelioma Reveals Differences in Immunogenicity
Previous Article in Special Issue
Genomic Landscape of Hodgkin Lymphoma
Article

Rituximab-Containing Risk-Adapted Treatment Strategy in Nodular Lymphocyte Predominant Hodgkin Lymphoma: 7-Years Follow-Up

1
Department of Clinical Medicine and Surgery, Hematology Section, University of Naples “Federico II”, Via Sergio Pansini, 5, 80131 Naples, Italy
2
Pathology Unit, Department of Advanced Biomedical Sciences, University of Naples “Federico II”, Via Sergio Pansini, 5, 80131 Naples, Italy
*
Author to whom correspondence should be addressed.
Academic Editor: Thomas Wirth
Cancers 2021, 13(8), 1760; https://doi.org/10.3390/cancers13081760
Received: 17 February 2021 / Revised: 26 March 2021 / Accepted: 29 March 2021 / Published: 7 April 2021
(This article belongs to the Special Issue Recent Advances in Hodgkin’s Lymphoma)
The current literature on NLPHL therapy is scarce due to the disease rarity. Our study aims to focus on the management and treatment strategies of NLPHL based on risk stratification. This paper contributes to the current literature, based mainly on retrospective studies and on small cohort studies, confirming the benefit of Rituximab for patients with NLPHL, in particular for those with advanced disease. We hope that our results can be confirmed by larger cohort studies from the research community.
Background: Nodular lymphocyte predominant Hodgkin lymphoma (NLPHL) is a rare variant of HL that accounts for 5% of all HL cases. The expression of CD20 on neoplastic lymphocytes provides a suitable target for novel treatments based on Rituximab. Due to its rarity, consolidated and widely accepted treatment guidelines are still lacking for this disease. Methods: Between 1 December 2007 and 28 February 2018, sixteen consecutive newly diagnosed adult patients with NLPHL received Rituximab (induction ± maintenance)-based therapy, according to the baseline risk of German Hodgkin Study Group prognostic score system. The treatment efficacy and safety of the Rituximab-group were compared to those of a historical cohort of 12 patients with NLPHL who received Doxorubicin, Bleomycin, Vinblastine, Dacarbazine (ABVD) chemotherapy followed by radiotherapy (RT), if needed, according to a similar baseline risk. The primary outcome was progression-free survival (PFS) and secondary outcomes were overall survival (OS) and side-effects (according to the Common Terminology Criteria for Adverse Events, v4.03). Results: After a 7-year follow-up (range, 1–11 years), PFS was 100% for patients treated with the Rituximab-containing regimen versus 66% for patients of the historical cohort (p = 0.036). Four patients in the latter group showed insufficient response to therapy. The PFS for early favorable and early unfavorable NLPHLs was similar between treatment groups, while a better PFS was recorded for advanced-stages treated with the Rituximab-containing regimen. The OS was similar for the two treatment groups. Short- and long-term side-effects were more frequently observed in the historical cohort. Grade ≥3 neutropenia was more frequent in the historical cohort compared with the Rituximab-group (58.3% vs. 18.7%, respectively; p = 0.03). Long-term non-hematological toxicities were observed more frequently in the historical cohort. Conclusion: Our results confirm the value of Rituximab in NLPHL therapy and show that Rituximab (single-agent) induction and maintenance in a limited-stage, or Rituximab with ABVD only in the presence of risk factors, give excellent results while sparing cytotoxic agent- and/or RT-related damage. Furthermore, Rituximab inclusion in advanced-stage therapeutic strategy seems to improve PFS compared to conventional chemo-radiotherapy. View Full-Text
Keywords: nodular lymphocyte predominant hodgkin lymphoma; rituximab; progression-free survival nodular lymphocyte predominant hodgkin lymphoma; rituximab; progression-free survival
Show Figures

Figure 1

MDPI and ACS Style

Pugliese, N.; Picardi, M.; Della Pepa, R.; Giordano, C.; Muriano, F.; Leone, A.; Delle Cave, G.; D’Ambrosio, A.; Marafioti, V.; Rascato, M.G.; Russo, D.; Mascolo, M.; Pane, F. Rituximab-Containing Risk-Adapted Treatment Strategy in Nodular Lymphocyte Predominant Hodgkin Lymphoma: 7-Years Follow-Up. Cancers 2021, 13, 1760. https://doi.org/10.3390/cancers13081760

AMA Style

Pugliese N, Picardi M, Della Pepa R, Giordano C, Muriano F, Leone A, Delle Cave G, D’Ambrosio A, Marafioti V, Rascato MG, Russo D, Mascolo M, Pane F. Rituximab-Containing Risk-Adapted Treatment Strategy in Nodular Lymphocyte Predominant Hodgkin Lymphoma: 7-Years Follow-Up. Cancers. 2021; 13(8):1760. https://doi.org/10.3390/cancers13081760

Chicago/Turabian Style

Pugliese, Novella; Picardi, Marco; Della Pepa, Roberta; Giordano, Claudia; Muriano, Francesco; Leone, Aldo; Delle Cave, Giuseppe; D’Ambrosio, Alessandro; Marafioti, Violetta; Rascato, Maria G.; Russo, Daniela; Mascolo, Massimo; Pane, Fabrizio. 2021. "Rituximab-Containing Risk-Adapted Treatment Strategy in Nodular Lymphocyte Predominant Hodgkin Lymphoma: 7-Years Follow-Up" Cancers 13, no. 8: 1760. https://doi.org/10.3390/cancers13081760

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Search more from Scilit
 
Search
Back to TopTop