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Open AccessReview

Molecular Mechanisms of Senescence and Implications for the Treatment of Myeloid Malignancies

by 1,2 and 3,4,*
1
Internal Medicine 2, Hematology and Oncology, Jena University Hospital, 07747 Jena, Germany
2
Research Program “Else Kröner-Forschungskolleg AntiAge“, Jena University Hospital, 07747 Jena, Germany
3
Internal Medicine C, Hematology and Oncology, Stem Cell Transplantation and Palliative Care, Greifswald University Medicine, 17475 Greifswald, Germany
4
Leibniz Institute on Aging, Fritz-Lipmann Institute, 07745 Jena, Germany
*
Author to whom correspondence should be addressed.
Academic Editor: Hiroshi Handa
Cancers 2021, 13(4), 612; https://doi.org/10.3390/cancers13040612
Received: 18 January 2021 / Revised: 30 January 2021 / Accepted: 1 February 2021 / Published: 4 February 2021
(This article belongs to the Special Issue Neurodegeneration and Cancers)
Senescence is a cellular program in response to stress and can prevent the expansion of pre-malignant and malignant cells by cell cycle arrest. However, long-term pro-tumorigenic effects have been described. This review aims to compile molecular mechanisms of cellular senescence and to discuss potential therapeutic implications in myeloid malignancies.
Senescence is a cellular state that is involved in aging-associated diseases but may also prohibit the development of pre-cancerous lesions and tumor growth. Senescent cells are actively secreting chemo- and cytokines, and this senescence-associated secretory phenotype (SASP) can contribute to both early anti-tumorigenic and long-term pro-tumorigenic effects. Recently, complex mechanisms of cellular senescence and their influence on cellular processes have been defined in more detail and, therefore, facilitate translational development of targeted therapies. In this review, we aim to discuss major molecular pathways involved in cellular senescence and potential therapeutic strategies, with a specific focus on myeloid malignancies. View Full-Text
Keywords: senescence; SASP; leukemia; myeloproliferative neoplasms; myelodysplastic syndrome; senolytics senescence; SASP; leukemia; myeloproliferative neoplasms; myelodysplastic syndrome; senolytics
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MDPI and ACS Style

Ernst, P.; Heidel, F.H. Molecular Mechanisms of Senescence and Implications for the Treatment of Myeloid Malignancies. Cancers 2021, 13, 612. https://doi.org/10.3390/cancers13040612

AMA Style

Ernst P, Heidel FH. Molecular Mechanisms of Senescence and Implications for the Treatment of Myeloid Malignancies. Cancers. 2021; 13(4):612. https://doi.org/10.3390/cancers13040612

Chicago/Turabian Style

Ernst, Philipp; Heidel, Florian H. 2021. "Molecular Mechanisms of Senescence and Implications for the Treatment of Myeloid Malignancies" Cancers 13, no. 4: 612. https://doi.org/10.3390/cancers13040612

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