Next Article in Journal
Relationship between Treatment Plan Dosimetry, Toxicity, and Survival following Intensity-Modulated Radiotherapy, with or without Chemotherapy, for Stage III Inoperable Non-Small Cell Lung Cancer
Previous Article in Journal
Difference in Estimation of Side Effects of Chemotherapy between Physicians and Patients with Early-Stage Breast Cancer: The Use of Patient Reported Outcomes (PROs) in the Evaluation of Toxicity in Everyday Clinical Practice
Article

The Clinical Feature and Treatment Outcome of Ocular Melanoma: A 34-Year Experience in a Tertiary Referral Center

by 1,2,3,†, 1,2,3,4,†, 1,2,3, 1,2,3,*, 1,2,3, 1,2,3,5 and 1,2,3
1
Department of Ophthalmology, Taipei Veterans General Hospital, Taipei 11217, Taiwan
2
School of Medicine, National Yang Ming University, Taipei 11221, Taiwan
3
School of Medicine, National Yang Ming Chiao Tung University, Hsinchu 30010, Taiwan
4
Department of Ophthalmology, Kaohsiung Veterans General Hospital, Kaohsiung 813414, Taiwan
5
Department of Ophthalmology, Taipei Medical University-Shuang-Ho Hospital, Ministry of Health and Welfare, New Taipei City 23561, Taiwan
*
Author to whom correspondence should be addressed.
These authors share first authorship.
Academic Editor: Hakan Demirci
Cancers 2021, 13(23), 5926; https://doi.org/10.3390/cancers13235926 (registering DOI)
Received: 23 October 2021 / Revised: 23 November 2021 / Accepted: 23 November 2021 / Published: 25 November 2021
(This article belongs to the Special Issue Advances in Eye Cancer Research and Clinical Management)
Although uncommonly encountered, ocular melanoma may threaten the vision and even the life of a patient. The clinical feature and long-term results of ocular melanoma have rarely been described in the Asian population, as it has a low incidence for non-Caucasians. Therefore, we investigated the epidemiology, clinical manifestation, treatment strategy, and long-term outcome of ocular melanoma in a tertiary referral center in Taiwan.
Malignant melanoma can arise from melanocytes in various structures of the eye, orbit, and ocular adnexa. We reviewed the clinical features and long-term results of all subjects with histologically proved melanoma originating from any of the ocular and periocular structures in a tertiary referral center. Overall, 88 patients including 47 men were recruited. The tumor was primarily located in the uvea, followed by the conjunctiva, orbit, eyelid, and lacrimal sac. Patients with uveal melanoma were diagnosed at a relatively younger age (47.0 years), while those with orbital and eyelid melanomas were older at presentation (79.5 years and 78.5 years, respectively). The overall local recurrence rate was 9% at a median follow-up of 41.0 months, among which orbital and eyelid melanomas recurred most commonly. The overall mortality rate was 41% in a median duration of 27.2 months (IQR, 13–58 months) from diagnosis, with the highest for lacrimal sac melanoma, followed by melanoma of the orbit, uveal, conjunctiva, and eyelid. Despite prompt local control, the risk for metastasis and mortality was high. Therefore, efficient modalities for early diagnosis and treatment of ocular melanoma are necessary. View Full-Text
Keywords: conjunctival melanoma; eyelid melanoma; ocular melanoma; orbital melanoma; uveal melanoma conjunctival melanoma; eyelid melanoma; ocular melanoma; orbital melanoma; uveal melanoma
Show Figures

Figure 1

MDPI and ACS Style

Huang, Y.-Y.; Hou, T.-Y.; Yu, W.-K.; Tsai, C.-C.; Kao, S.-C.; Hsu, W.-M.; Liu, J.-L. The Clinical Feature and Treatment Outcome of Ocular Melanoma: A 34-Year Experience in a Tertiary Referral Center. Cancers 2021, 13, 5926. https://doi.org/10.3390/cancers13235926

AMA Style

Huang Y-Y, Hou T-Y, Yu W-K, Tsai C-C, Kao S-C, Hsu W-M, Liu J-L. The Clinical Feature and Treatment Outcome of Ocular Melanoma: A 34-Year Experience in a Tertiary Referral Center. Cancers. 2021; 13(23):5926. https://doi.org/10.3390/cancers13235926

Chicago/Turabian Style

Huang, Yu-Yun, Tzu-Yu Hou, Wei-Kuang Yu, Chieh-Chih Tsai, Shu-Ching Kao, Wen-Ming Hsu, and Jui-Ling Liu 2021. "The Clinical Feature and Treatment Outcome of Ocular Melanoma: A 34-Year Experience in a Tertiary Referral Center" Cancers 13, no. 23: 5926. https://doi.org/10.3390/cancers13235926

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop