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Article

A Novel Four-Gene Prognostic Signature for Prediction of Survival in Patients with Soft Tissue Sarcoma

1
Institute of Anatomy, University of Leipzig, Liebigstraße 20, 04103 Leipzig, Germany
2
Sarcoma Center, Department of Orthopedics, Trauma and Plastic Surgery, University Hospital Leipzig, 04103 Leipzig, Germany
*
Author to whom correspondence should be addressed.
Academic Editor: Armita Bahrami
Cancers 2021, 13(22), 5837; https://doi.org/10.3390/cancers13225837
Received: 14 October 2021 / Revised: 16 November 2021 / Accepted: 20 November 2021 / Published: 21 November 2021
(This article belongs to the Topic Application of Big Medical Data in Precision Medicine)
Soft tissue sarcomas (STS) still lack effective clinical stratification and prognostic models. The aim of this study is to establish a reliable prognostic gene signature in STS. Using 189 STS samples from the TCGA database, a four-gene signature (including DHRS3, JRK, TARDBP and TTC3) and nomograms that can be used to predict the overall survival and relapse free survival of STS patients was developed. The predictive ability for metastasis free survival was externally verified in the GEO cohort. We demonstrated that the novel gene signature provides an attractive platform for risk stratification and prognosis prediction of STS patients, which is of great importance for individualized clinical treatment and long-term management of patients with this rare and severe disease.
Soft tissue sarcomas (STS), a group of rare malignant tumours with high tissue heterogeneity, still lack effective clinical stratification and prognostic models. Therefore, we conducted this study to establish a reliable prognostic gene signature. Using 189 STS patients’ data from The Cancer Genome Atlas database, a four-gene signature including DHRS3, JRK, TARDBP and TTC3 was established. A risk score based on this gene signature was able to divide STS patients into a low-risk and a high-risk group. The latter had significantly worse overall survival (OS) and relapse free survival (RFS), and Cox regression analyses showed that the risk score is an independent prognostic factor. Nomograms containing the four-gene signature have also been established and have been verified through calibration curves. In addition, the predictive ability of this four-gene signature for STS metastasis free survival was verified in an independent cohort (309 STS patients from the Gene Expression Omnibus database). Finally, Gene Set Enrichment Analysis indicated that the four-gene signature may be related to some pathways associated with tumorigenesis, growth, and metastasis. In conclusion, our study establishes a novel four-gene signature and clinically feasible nomograms to predict the OS and RFS. This can help personalized treatment decisions, long-term patient management, and possible future development of targeted therapy. View Full-Text
Keywords: soft tissue sarcomas; gene signature; prognosis; nomogram soft tissue sarcomas; gene signature; prognosis; nomogram
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MDPI and ACS Style

Wu, C.; Gong, S.; Osterhoff, G.; Schopow, N. A Novel Four-Gene Prognostic Signature for Prediction of Survival in Patients with Soft Tissue Sarcoma. Cancers 2021, 13, 5837. https://doi.org/10.3390/cancers13225837

AMA Style

Wu C, Gong S, Osterhoff G, Schopow N. A Novel Four-Gene Prognostic Signature for Prediction of Survival in Patients with Soft Tissue Sarcoma. Cancers. 2021; 13(22):5837. https://doi.org/10.3390/cancers13225837

Chicago/Turabian Style

Wu, Changwu, Siming Gong, Georg Osterhoff, and Nikolas Schopow. 2021. "A Novel Four-Gene Prognostic Signature for Prediction of Survival in Patients with Soft Tissue Sarcoma" Cancers 13, no. 22: 5837. https://doi.org/10.3390/cancers13225837

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