Disruption of Tumor Suppressors HNF4α/HNF1α Causes Tumorigenesis in Liver
Abstract
:Simple Summary
Abstract
1. Introduction
2. The Roles of HNF4α and HNF1α in Liver Cancer Development
2.1. HNF4α and HNF1α as a Link between Inflammation and Cancer
2.2. HNF4α and HNF1α in Epithelial-to-Mesenchymal Transition (EMT) and Liver Cancer Metastasis
2.3. HNF4α and HNF1α in Metabolism and Liver Cancer
2.4. HNF4α and HNF1α Mutations in Liver Cancer
2.5. Phenotypic Consequences of Downregulated Expression of HNF4α and HNF1α in Liver Cancer
2.6. Disruptions of Epigenetic and miRNA Controls in HNF4α and HNF1α Networks Contribute to Cancer Development in Liver Cancer
2.7. Function of HNF4α and HNF1α Is Disrupted by HBV and HCV Infection
2.8. HNF4α in Colorectal Cancer (CRC): Friend or Foe?
3. HNF4α as a Therapeutic Target in Cancer
4. Conclusions
Author Contributions
Funding
Conflicts of Interest
References
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Teeli, A.S.; Łuczyńska, K.; Haque, E.; Gayas, M.A.; Winiarczyk, D.; Taniguchi, H. Disruption of Tumor Suppressors HNF4α/HNF1α Causes Tumorigenesis in Liver. Cancers 2021, 13, 5357. https://doi.org/10.3390/cancers13215357
Teeli AS, Łuczyńska K, Haque E, Gayas MA, Winiarczyk D, Taniguchi H. Disruption of Tumor Suppressors HNF4α/HNF1α Causes Tumorigenesis in Liver. Cancers. 2021; 13(21):5357. https://doi.org/10.3390/cancers13215357
Chicago/Turabian StyleTeeli, Aamir Salam, Kamila Łuczyńska, Effi Haque, Mohmmad Abrar Gayas, Dawid Winiarczyk, and Hiroaki Taniguchi. 2021. "Disruption of Tumor Suppressors HNF4α/HNF1α Causes Tumorigenesis in Liver" Cancers 13, no. 21: 5357. https://doi.org/10.3390/cancers13215357