Next Article in Journal
Dynamic Interplay between Lower-Grade Glioma Instability and Brain Metaplasticity: Proposal of an Original Model to Guide the Therapeutic Strategy
Previous Article in Journal
Analysis of Telomere Maintenance Related Genes Reveals NOP10 as a New Metastatic-Risk Marker in Pheochromocytoma/Paraganglioma
Review

Recent Advances in the Management of Patients with Non-Muscle-Invasive Bladder Cancer Using a Multidisciplinary Approach: Practical Recommendations from the Spanish Oncology Genitourinary (SOGUG) Working Group

1
Urology Department, Instituto Valenciano de Oncología & Hospital VITHAS 9 de Octubre, 06009 Valencia, Spain
2
Pathology Section Fundació Puigvert, Universitat Autònoma de Barcelona, 08025 Barcelona, Spain
3
Oncology Department, Parc Taulí Hospital Universitari, Institut d’Investigació i Innovació Parc Taulí I3PT, Universitat Autònoma de Barcelona, 08208 Sabadell, Spain
4
Hospital Universitario Virgen Macarena, 41009 Sevilla, Spain
5
Medical Oncology Service, Fundación Instituto Valenciano de Oncología, 46009 Valencia, Spain
*
Author to whom correspondence should be addressed.
SOGUG Multidisciplinary Working Group are listed in acknowledgments.
Academic Editor: Tarek A. Bismar
Cancers 2021, 13(19), 4762; https://doi.org/10.3390/cancers13194762
Received: 17 August 2021 / Revised: 15 September 2021 / Accepted: 20 September 2021 / Published: 23 September 2021
This report presents clinically relevant advances in the management of non-muscle-invasive bladder cancer, which have been the focus of discussion of expert members of the Spanish Oncology Genitourinary (SOGUG) Multidisciplinary Working Group in the framework of the Genitourinary Alliance project (12GU), designed as a space for the integration of novel information in the care of bladder cancer patients. The present study is focused on different aspects regarding the evaluation of hematuria, assessment of second (or repeated) transurethral resection of bladder cancer, histopathological diagnosis and problems with tumor grading, importance of histological variants, shortage of drug supply, and the current role and influence of immunotherapy and biological markers on the oncological outcome of patients. All proposals and recommendations have a multidisciplinary practical approach and are intended to help clinicians in shared decision making for patients with non-muscle-invasive urothelial cancer.
On the basis of the discussion of the current state of research on relevant topics of non-muscle-invasive bladder cancer (NMIBC) among a group of experts of the Spanish Oncology Genitourinary (SOGUG) Working Group, recommendations were proposed to overcome the challenges posed by the management of NMIBC in clinical practice. A unified definition of the term ‘microhematuria’ and the profile of the patient at risk are needed. Establishing a ‘hematuria clinic’ would contribute to a centralized and more efficient evaluation of patients with this clinical sign. Second or repeated transurethral resection (re-TUR) needs to be defined, including the time window after the first procedure within which re-TUR should be performed. Complete tumor resection is mandatory when feasible, with specification of the presence or absence of muscle. Budding should be used as a classification system, and stratification of T1 tumors especially in extensive and deep tumors, is advisable. The percentage of the high-grade component should always be reported, and, in multiple tumors, grades should be reported separately. Luminal and basal subtypes can be identified because of possibly different clinical outcomes. Molecular subtypes and immunotherapy are incorporated in the management of muscle-invasive bladder cancer but data on NMIBC are still preliminary. View Full-Text
Keywords: non-muscle-invasive bladder cancer; microhematuria; transurethral resection; histological variants; molecular subtypes; immunotherapy non-muscle-invasive bladder cancer; microhematuria; transurethral resection; histological variants; molecular subtypes; immunotherapy
Show Figures

Figure 1

MDPI and ACS Style

Rubio-Briones, J.; Algaba, F.; Gallardo, E.; Marcos-Rodríguez, J.A.; Climent, M.Á.; on behalf of the SOGUG Multidisciplinary Working Group. Recent Advances in the Management of Patients with Non-Muscle-Invasive Bladder Cancer Using a Multidisciplinary Approach: Practical Recommendations from the Spanish Oncology Genitourinary (SOGUG) Working Group. Cancers 2021, 13, 4762. https://doi.org/10.3390/cancers13194762

AMA Style

Rubio-Briones J, Algaba F, Gallardo E, Marcos-Rodríguez JA, Climent MÁ, on behalf of the SOGUG Multidisciplinary Working Group. Recent Advances in the Management of Patients with Non-Muscle-Invasive Bladder Cancer Using a Multidisciplinary Approach: Practical Recommendations from the Spanish Oncology Genitourinary (SOGUG) Working Group. Cancers. 2021; 13(19):4762. https://doi.org/10.3390/cancers13194762

Chicago/Turabian Style

Rubio-Briones, José, Ferran Algaba, Enrique Gallardo, José A. Marcos-Rodríguez, Miguel Á. Climent, and on behalf of the SOGUG Multidisciplinary Working Group. 2021. "Recent Advances in the Management of Patients with Non-Muscle-Invasive Bladder Cancer Using a Multidisciplinary Approach: Practical Recommendations from the Spanish Oncology Genitourinary (SOGUG) Working Group" Cancers 13, no. 19: 4762. https://doi.org/10.3390/cancers13194762

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop