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Article

Multi-Institutional Retrospective Analysis of Carbon-Ion Radiotherapy for Patients with Locally Advanced Adenocarcinoma of the Uterine Cervix

1
National Institutes for Quantum and Radiological Science and Technology, QST Hospital, Chiba 263-8555, Japan
2
Department of Radiation Oncology, Gunma University Graduate School of Medicine, Maebashi 371-8511, Japan
3
Department of Radiation Oncology, Saitama Medical University International Medical Center, Hidaka 350-1298, Japan
4
Department of Reproductive Medicine, Chiba University Graduate School of Medicine, Chiba 260-8677, Japan
*
Author to whom correspondence should be addressed.
These authors contributed to this study equally.
Academic Editor: Arya Amini
Cancers 2021, 13(11), 2713; https://doi.org/10.3390/cancers13112713
Received: 22 May 2021 / Accepted: 27 May 2021 / Published: 31 May 2021
(This article belongs to the Special Issue Role of Radiation in the Treatment of Cancer)
We conducted a multi-institutional survey of carbon-ion radiotherapy (CIRT) for locally advanced adenocarcinoma (LAAC) of the uterine cervix. We retrospectively analyzed the clinical outcomes of patients with stage IIB–IVA LAAC of the uterine cervix who underwent chemo-CIRT or CIRT alone between April 2010 and April 2016. Fifty-five patients were enrolled in this study. The median follow-up period was 67.5 months. The 5-year overall survival (OS) and local control (LC) rates were 68.6% and 65.2%, respectively. Multivariate analysis showed that the initial tumor response within 6 months was significantly associated with LC and OS. The present study represents promising outcomes of CIRT or chemo-CIRT for LAAC of the uterine cervix, especially in the cases showing initial rapid regression of the tumor.
The clinical significance of carbon-ion radiotherapy (CIRT) for adenocarcinoma (AC) of the uterine cervix has been assessed in several single-institutional studies. To validate the significance, we conducted a multi-institutional survey of CIRT for locally advanced AC (LAAC) of the uterine cervix. We retrospectively analyzed the clinical outcomes of patients with stage IIB–IVA LAAC of the uterine cervix who underwent chemo-CIRT or CIRT alone between April 2010 and April 2016. Patients received 74.4 Gy (relative biological effectiveness [RBE]) in 20 fractions of CIRT or 55.2 Gy (RBE) in 16 fractions of CIRT plus three sessions of brachytherapy. Patients aged ≤ 70 years with adequate bone marrow and organ function were administered cisplatin weekly (40 mg/m2 per week for up to 5 weeks). Fifty-five patients were enrolled in this study. The median follow-up period was 67.5 months. The 5-year overall survival (OS) and local control (LC) rates were 68.6% and 65.2%, respectively. Multivariate analysis showed that the initial tumor response within 6 months was significantly associated with LC and OS. The present study represents promising outcomes of CIRT or chemo-CIRT for LAAC of the uterine cervix, especially in the cases showing initial rapid regression of the tumor. View Full-Text
Keywords: carbon-ion radiotherapy; uterine cervical cancer; adenocarcinoma; long-term follow-up; cisplatin; concurrent chemoradiotherapy carbon-ion radiotherapy; uterine cervical cancer; adenocarcinoma; long-term follow-up; cisplatin; concurrent chemoradiotherapy
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MDPI and ACS Style

Okonogi, N.; Ando, K.; Murata, K.; Wakatsuki, M.; Noda, S.-e.; Irie, D.; Tsuji, H.; Shozu, M.; Ohno, T. Multi-Institutional Retrospective Analysis of Carbon-Ion Radiotherapy for Patients with Locally Advanced Adenocarcinoma of the Uterine Cervix. Cancers 2021, 13, 2713. https://doi.org/10.3390/cancers13112713

AMA Style

Okonogi N, Ando K, Murata K, Wakatsuki M, Noda S-e, Irie D, Tsuji H, Shozu M, Ohno T. Multi-Institutional Retrospective Analysis of Carbon-Ion Radiotherapy for Patients with Locally Advanced Adenocarcinoma of the Uterine Cervix. Cancers. 2021; 13(11):2713. https://doi.org/10.3390/cancers13112713

Chicago/Turabian Style

Okonogi, Noriyuki, Ken Ando, Kazutoshi Murata, Masaru Wakatsuki, Shin-ei Noda, Daisuke Irie, Hiroshi Tsuji, Makio Shozu, and Tatsuya Ohno. 2021. "Multi-Institutional Retrospective Analysis of Carbon-Ion Radiotherapy for Patients with Locally Advanced Adenocarcinoma of the Uterine Cervix" Cancers 13, no. 11: 2713. https://doi.org/10.3390/cancers13112713

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