Targeted Therapies for Melanoma
Institute of Anatomy, 1st Faculty of Medicine, Charles University, 128 00 Prague, Czech Republic
BIOCEV, 1st Faculty of Medicine, Charles University, 252 50 Vestec, Czech Republic
Department of Dermatovenereology, 1st Faculty of Medicine, Charles University and General University Hospital, 128 08 Prague, Czech Republic
Author to whom correspondence should be addressed.
Received: 31 August 2020 / Accepted: 1 September 2020 / Published: 3 September 2020
The incidence of cutaneous malignant melanoma is increasing worldwide. Despite available modern therapeutical options, long-term survival of patients in advanced stages of the disease remains rather limited until now. Detailed insights into etiopathogenesis and mechanisms of tumour progression enable physicians to manipulate distinct molecular structures and pathways therapeutically and so treat the tumour. Unfortunately, the acquisition of therapeutic resistance frequently terminates these therapeutical interventions. The presented special issue is focusing on the research and therapeutic experience of leading scientists, and it summarises the state of the art of targeted therapy of melanoma and suggests the new perspectives of the treatment of disease.