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Diagnosis and Treatment of Bone Metastases in Breast Cancer: Radiotherapy, Local Approach and Systemic Therapy in a Guide for Clinicians

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“A. Gemelli” IRCCS, UOC di Radioterapia Oncologica, Dipartimento di Diagnostica per Immagini, Radioterapia Oncologica ed Ematologia, Fondazione Policlinico Universitario, 00168 Roma, Italy
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“A. Gemelli” IRCCS, UOC di Oncologia Medica, Dipartimento di Scienze Mediche e Chirurgiche, Fondazione Policlinico Universitario, 00168 Roma, Italy
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“A. Gemelli” IRCCS, UOC di Chirurgia Senologica, Dipartimento di Scienze della Salute della Donna e del Bambino e di Sanità Pubblica, Fondazione Policlinico Universitario, 00168 Roma, Italy
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Istituto di Radiologia, Università Cattolica del Sacro Cuore, 00168 Roma, Italy
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Author to whom correspondence should be addressed.
Cancers 2020, 12(9), 2390; https://doi.org/10.3390/cancers12092390
Received: 1 May 2020 / Revised: 13 August 2020 / Accepted: 20 August 2020 / Published: 24 August 2020
(This article belongs to the Special Issue Targeting Bone Metastasis in Cancers)
The standard care for metastatic breast cancer (MBC) is systemic therapies with imbrication of focal treatment for symptoms. Recently, thanks to implementation of radiological and metabolic exams and development of new target therapies, oligometastatic and oligoprogressive settings are even more common—paving the way to a paradigm change of focal treatments role. In fact, according to immunophenotype, radiotherapy can be considered with radical intent in these settings of patients. The aim of this literature review is to analyze available clinical data on prognosis of bone metastases from breast cancer and benefits of available treatments for developing a practical guide for clinicians. View Full-Text
Keywords: bone metastasis; breast cancer; radiotherapy; diagnostic imaging; systemic therapies bone metastasis; breast cancer; radiotherapy; diagnostic imaging; systemic therapies
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MDPI and ACS Style

Marazzi, F.; Orlandi, A.; Manfrida, S.; Masiello, V.; Di Leone, A.; Massaccesi, M.; Moschella, F.; Franceschini, G.; Bria, E.; Gambacorta, M.A.; Masetti, R.; Tortora, G.; Valentini, V. Diagnosis and Treatment of Bone Metastases in Breast Cancer: Radiotherapy, Local Approach and Systemic Therapy in a Guide for Clinicians. Cancers 2020, 12, 2390. https://doi.org/10.3390/cancers12092390

AMA Style

Marazzi F, Orlandi A, Manfrida S, Masiello V, Di Leone A, Massaccesi M, Moschella F, Franceschini G, Bria E, Gambacorta MA, Masetti R, Tortora G, Valentini V. Diagnosis and Treatment of Bone Metastases in Breast Cancer: Radiotherapy, Local Approach and Systemic Therapy in a Guide for Clinicians. Cancers. 2020; 12(9):2390. https://doi.org/10.3390/cancers12092390

Chicago/Turabian Style

Marazzi, Fabio, Armando Orlandi, Stefania Manfrida, Valeria Masiello, Alba Di Leone, Mariangela Massaccesi, Francesca Moschella, Gianluca Franceschini, Emilio Bria, Maria A. Gambacorta, Riccardo Masetti, Giampaolo Tortora, and Vincenzo Valentini. 2020. "Diagnosis and Treatment of Bone Metastases in Breast Cancer: Radiotherapy, Local Approach and Systemic Therapy in a Guide for Clinicians" Cancers 12, no. 9: 2390. https://doi.org/10.3390/cancers12092390

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