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Proteotoxic Stress and Cell Death in Cancer Cells

Department of Medicine, Università degli Studi di Udine, p.le Kolbe 4—33100 Udine, Italy
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Cancers 2020, 12(9), 2385; https://doi.org/10.3390/cancers12092385
Received: 14 July 2020 / Revised: 19 August 2020 / Accepted: 20 August 2020 / Published: 23 August 2020
(This article belongs to the Special Issue Deregulation of Cell Death in Cancer)
To maintain proteostasis, cells must integrate information and activities that supervise protein synthesis, protein folding, conformational stability, and also protein degradation. Extrinsic and intrinsic conditions can both impact normal proteostasis, causing the appearance of proteotoxic stress. Initially, proteotoxic stress elicits adaptive responses aimed at restoring proteostasis, allowing cells to survive the stress condition. However, if the proteostasis restoration fails, a permanent and sustained proteotoxic stress can be deleterious, and cell death ensues. Many cancer cells convive with high levels of proteotoxic stress, and this condition could be exploited from a therapeutic perspective. Understanding the cell death pathways engaged by proteotoxic stress is instrumental to better hijack the proliferative fate of cancer cells. View Full-Text
Keywords: UPR; NOXA; DR5; BCL2; apoptosis; necroptosis; ferroptosis; proteotoxic stress UPR; NOXA; DR5; BCL2; apoptosis; necroptosis; ferroptosis; proteotoxic stress
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Brancolini, C.; Iuliano, L. Proteotoxic Stress and Cell Death in Cancer Cells. Cancers 2020, 12, 2385.

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