Next Article in Journal
Genetic Counseling for Hereditary Gastric and Pancreatic Cancer in High-Risk Gastrointestinal Cancer Clinics: An Effective Strategy
Next Article in Special Issue
Development of a Cationic Amphiphilic Helical Peptidomimetic (B18L) As A Novel Anti-Cancer Drug Lead
Previous Article in Journal
Marker Identification of the Grade of Dysplasia of Intraductal Papillary Mucinous Neoplasm in Pancreatic Cyst Fluid by Quantitative Proteomic Profiling
Previous Article in Special Issue
Relation of Neutrophil Gelatinase-Associated Lipocalin Overexpression to the Resistance to Apoptosis of Tumor B Cells in Chronic Lymphocytic Leukemia

Proteotoxic Stress and Cell Death in Cancer Cells

Department of Medicine, Università degli Studi di Udine, p.le Kolbe 4—33100 Udine, Italy
Author to whom correspondence should be addressed.
Cancers 2020, 12(9), 2385;
Received: 14 July 2020 / Revised: 19 August 2020 / Accepted: 20 August 2020 / Published: 23 August 2020
(This article belongs to the Special Issue Deregulation of Cell Death in Cancer)
To maintain proteostasis, cells must integrate information and activities that supervise protein synthesis, protein folding, conformational stability, and also protein degradation. Extrinsic and intrinsic conditions can both impact normal proteostasis, causing the appearance of proteotoxic stress. Initially, proteotoxic stress elicits adaptive responses aimed at restoring proteostasis, allowing cells to survive the stress condition. However, if the proteostasis restoration fails, a permanent and sustained proteotoxic stress can be deleterious, and cell death ensues. Many cancer cells convive with high levels of proteotoxic stress, and this condition could be exploited from a therapeutic perspective. Understanding the cell death pathways engaged by proteotoxic stress is instrumental to better hijack the proliferative fate of cancer cells. View Full-Text
Keywords: UPR; NOXA; DR5; BCL2; apoptosis; necroptosis; ferroptosis; proteotoxic stress UPR; NOXA; DR5; BCL2; apoptosis; necroptosis; ferroptosis; proteotoxic stress
Show Figures

Figure 1

MDPI and ACS Style

Brancolini, C.; Iuliano, L. Proteotoxic Stress and Cell Death in Cancer Cells. Cancers 2020, 12, 2385.

AMA Style

Brancolini C, Iuliano L. Proteotoxic Stress and Cell Death in Cancer Cells. Cancers. 2020; 12(9):2385.

Chicago/Turabian Style

Brancolini, Claudio, and Luca Iuliano. 2020. "Proteotoxic Stress and Cell Death in Cancer Cells" Cancers 12, no. 9: 2385.

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

Back to TopTop