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Open AccessArticle

Detection of Oral Dysplastic and Early Cancerous Lesions by Polarization-Sensitive Optical Coherence Tomography

1
Department of Gastroenterology, West Garden Hospital, Taipei 108, Taiwan
2
Endoscopy Center for Diagnosis and Treatment, Taipei Veterans General Hospital, Taipei 112, Taiwan
3
Department of Medicine, National Yang-Ming University, Taipei 112, Taiwan
4
Institute of Biophotonics, National Yang-Ming University, Taipei 112, Taiwan
5
Institute of Oral Biology, National Yang-Ming University, Taipei 112, Taiwan
6
Department of Pathology and Laboratory Medicine, Taipei Veterans General Hospital, Taipei 112, Taiwan
7
Department of Dentistry, National Yang-Ming University, Taipei 112, Taiwan
8
Department of Stomatology, Taipei Veterans General Hospital, Taipei 112, Taiwan
9
Department of Internal Medicine, Taipei Veterans General Hospital, Taipei 112, Taiwan
*
Author to whom correspondence should be addressed.
Cancers 2020, 12(9), 2376; https://doi.org/10.3390/cancers12092376
Received: 26 June 2020 / Revised: 14 August 2020 / Accepted: 19 August 2020 / Published: 22 August 2020
(This article belongs to the Section Methods and Technologies Development)
Detection of oral dysplastic and early-stage cancerous lesions is difficult with the current tools. Half of oral cancers are diagnosed in a late stage. Detection of early stromal change to predict malignant transformation is a new direction in the diagnosis of early-stage oral cancer. The application of new optical tools to image stroma in vivo is under investigation, and polarization-sensitive optical coherence tomography (PS-OCT) is potentially one of those tools. This is a preliminary study to sequentially image oral stromal changes from normal, hyperplasia, and dysplasia to early-stage cancer by PS-OCT in vivo. We used 4-Nitroquinoline-1-oxide drinking water to induce dysplasia and early-stage oral cancer in 19 K14-EGFP-miR-211-GFP transgenic mice. A total of 8 normal, 12 hyperplastic, 11 dysplastic, and 4 early-stage cancerous lesions were enrolled. A new analytic process of PS-OCT imaging was proposed, called an en-face birefringence map. From the birefringence map, the sensitivity, specificity, positive predictive value, and negative predictive values to detect dysplasia and early-stage cancer were 100.00%, 95.00%, 93.75%, and 100.00%, respectively, and the kappa value of these images between two investigators was 0.942. The mean size of malignant lesions detected in this study is 1.66 ± 0.93 mm. This pilot animal study validates the use of PS-OCT to detect small and early-stage oral malignancy with high accuracy and consistency. View Full-Text
Keywords: oral cancer; dysplasia; diagnosis; polarization-sensitive optical coherence tomography oral cancer; dysplasia; diagnosis; polarization-sensitive optical coherence tomography
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MDPI and ACS Style

Chen, P.-H.; Lee, H.-Y.; Chen, Y.-F.; Yeh, Y.-C.; Chang, K.-W.; Hou, M.-C.; Kuo, W.-C. Detection of Oral Dysplastic and Early Cancerous Lesions by Polarization-Sensitive Optical Coherence Tomography. Cancers 2020, 12, 2376. https://doi.org/10.3390/cancers12092376

AMA Style

Chen P-H, Lee H-Y, Chen Y-F, Yeh Y-C, Chang K-W, Hou M-C, Kuo W-C. Detection of Oral Dysplastic and Early Cancerous Lesions by Polarization-Sensitive Optical Coherence Tomography. Cancers. 2020; 12(9):2376. https://doi.org/10.3390/cancers12092376

Chicago/Turabian Style

Chen, Ping-Hsien; Lee, Hung-Yi; Chen, Yi-Fen; Yeh, Yi-Chen; Chang, Kuo-Wei; Hou, Ming-Chih; Kuo, Wen-Chuan. 2020. "Detection of Oral Dysplastic and Early Cancerous Lesions by Polarization-Sensitive Optical Coherence Tomography" Cancers 12, no. 9: 2376. https://doi.org/10.3390/cancers12092376

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