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Cancers
Volume 12
Issue 8
10.3390/cancers12082318
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Article

The Clinicopathological Characteristics And Genetic Alterations of Signet-ring Cell Carcinoma in Gastric Cancer

by
Kuo-Hung Huang
1,2,
Ming-Huang Chen
3,
Wen-Liang Fang
1,2,*,
Chien-Hsing Lin
4,
Yee Chao
2,3,
Su-Shun Lo
2,5,
Anna Fen-Yau Li
2,6,
Chew-Wun Wu
1,2 and
Yi-Ming Shyr
1,2
1
Division of General Surgery, Department of Surgery, Taipei Veterans General Hospital, Taipei 11217, Taiwan
2
School of Medicine, National Yang-Ming University, Taipei 11221, Taiwan
3
Center of Immuno-Oncology, Department of Oncology, Taipei Veterans General Hospital, Taipei 11217, Taiwan
4
Genome Research Center, National Yang-Ming University, Taipei 11221, Taiwan
5
Department of Surgery, National Yang-Ming University Hospital, Yilan 26058, Taiwan
6
Department of Pathology, Taipei Veterans General Hospital, Taipei 11217, Taiwan
*
Author to whom correspondence should be addressed.
Cancers 2020, 12(8), 2318; https://doi.org/10.3390/cancers12082318
Received: 12 July 2020 / Revised: 4 August 2020 / Accepted: 12 August 2020 / Published: 17 August 2020
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Abstract

Signet-ring cell carcinoma (SRC) in advanced gastric cancer (GC) is often associated with more invasiveness and a worse prognosis than other cell types. The genetic alterations associated with gastric carcinogenesis in SRC are still unclear. In this study, 441 GC patients receiving curative surgery for GC between 2005 and 2013 were enrolled. The clinicopathological characteristics and genetic alterations of GC patients with and without SRC were compared. Among the 441 GC patients, 181 had SRC. For early GC, patients with SRC had more tumors located in the middle and lower stomach, more infiltrating tumors and better overall survival (OS) rates than those without SRC. For advanced GC, patients with SRC had more scirrhous type tumors, more PIK3CA amplifications, fewer microsatellite instability-high (MSI-H) tumors, more peritoneal recurrences and worse 5-year OS rates than those without SRC. For advanced GC with SRC, patients with peritoneal recurrence tended to have PD-L1 expression. For advanced GC without SRC, patients with liver metastasis tended to have PD-L1 expression, PI3K/AKT pathway mutations, TP53 mutations and MSI-H tumors. For advanced GC, PD-L1 expression was associated with peritoneal recurrence in SRC tumors, while non-SRC tumors with liver metastasis were likely to have PI3K/AKT pathway mutations, TP53 mutations and PD-L1 expression; immunotherapy and targeted therapy may be beneficial for these patients. View Full-Text
Keywords: signet-ring cell; genetic alterations; advanced GC; PD-L1; recurrence pattern; prognostic factor review; meta-analysis signet-ring cell; genetic alterations; advanced GC; PD-L1; recurrence pattern; prognostic factor review; meta-analysis
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MDPI and ACS Style

Huang, K.-H.; Chen, M.-H.; Fang, W.-L.; Lin, C.-H.; Chao, Y.; Lo, S.-S.; Li, A.F.-Y.; Wu, C.-W.; Shyr, Y.-M. The Clinicopathological Characteristics And Genetic Alterations of Signet-ring Cell Carcinoma in Gastric Cancer. Cancers 2020, 12, 2318. https://doi.org/10.3390/cancers12082318

AMA Style

Huang K-H, Chen M-H, Fang W-L, Lin C-H, Chao Y, Lo S-S, Li AF-Y, Wu C-W, Shyr Y-M. The Clinicopathological Characteristics And Genetic Alterations of Signet-ring Cell Carcinoma in Gastric Cancer. Cancers. 2020; 12(8):2318. https://doi.org/10.3390/cancers12082318

Chicago/Turabian Style

Huang, Kuo-Hung, Ming-Huang Chen, Wen-Liang Fang, Chien-Hsing Lin, Yee Chao, Su-Shun Lo, Anna F.-Y. Li, Chew-Wun Wu, and Yi-Ming Shyr. 2020. "The Clinicopathological Characteristics And Genetic Alterations of Signet-ring Cell Carcinoma in Gastric Cancer" Cancers 12, no. 8: 2318. https://doi.org/10.3390/cancers12082318

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