Next Article in Journal
PKM2 Expression as Biomarker for Resistance to Oxaliplatin-Based Chemotherapy in Colorectal Cancer
Next Article in Special Issue
Amino Acids Regulate Cisplatin Insensitivity in Neuroblastoma
Previous Article in Journal
Downregulation of the DNA Repair Gene DDB2 by Arecoline Is through p53’s DNA-Binding Domain and Is Correlated with Poor Outcome of Head and Neck Cancer Patients with Betel Quid Consumption
Review

Targeting the Tumor Microenvironment in Neuroblastoma: Recent Advances and Future Directions

Department of Pediatrics, Division of Pediatric Hematology-Oncology, Moores Cancer Center, University of California San Diego, La Jolla, CA 92093-0815, USA
Cancers 2020, 12(8), 2057; https://doi.org/10.3390/cancers12082057
Received: 4 July 2020 / Revised: 21 July 2020 / Accepted: 23 July 2020 / Published: 25 July 2020
(This article belongs to the Special Issue The Tumor Microenvironment of Neuroblastoma)
Neuroblastoma (NB) is the most common pediatric tumor malignancy that originates from the neural crest and accounts for more than 15% of all the childhood deaths from cancer. The neuroblastoma cancer research has long been focused on the role of MYCN oncogene amplification and the contribution of other genetic alterations in the progression of this malignancy. However, it is now widely accepted that, not only tumor cells, but the components of tumor microenvironment (TME), including extracellular matrix, stromal cells and immune cells, also contribute to tumor progression in neuroblastoma. The complexity of different components of tumor stroma and their resemblance with surrounding normal tissues pose huge challenges for therapies targeting tumor microenvironment in NB. Hence, the detailed understanding of the composition of the TME of NB is crucial to improve existing and future potential immunotherapeutic approaches against this childhood cancer. In this review article, I will discuss different components of the TME of NB and the recent advances in the strategies, which are used to target the tumor microenvironment in neuroblastoma. View Full-Text
Keywords: tumor microenvironment; neuroblastoma; immunosuppression; hypoxia; extracellular matrix; metastasis tumor microenvironment; neuroblastoma; immunosuppression; hypoxia; extracellular matrix; metastasis
Show Figures

Figure 1

MDPI and ACS Style

Joshi, S. Targeting the Tumor Microenvironment in Neuroblastoma: Recent Advances and Future Directions. Cancers 2020, 12, 2057. https://doi.org/10.3390/cancers12082057

AMA Style

Joshi S. Targeting the Tumor Microenvironment in Neuroblastoma: Recent Advances and Future Directions. Cancers. 2020; 12(8):2057. https://doi.org/10.3390/cancers12082057

Chicago/Turabian Style

Joshi, Shweta. 2020. "Targeting the Tumor Microenvironment in Neuroblastoma: Recent Advances and Future Directions" Cancers 12, no. 8: 2057. https://doi.org/10.3390/cancers12082057

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Search more from Scilit
 
Search
Back to TopTop