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Anti-Cancer Potential of Cannabinoids, Terpenes, and Flavonoids Present in Cannabis

Department of Pharmacology, Faculty of Medicine, Dalhousie University, Halifax, NS B3H 4R2, Canada
Aquatic and Crop Resource Development Research Center, National Research Council of Canada, Halifax, NS B3H 3Z1, Canada
Author to whom correspondence should be addressed.
Contributed equally to this work.
Cancers 2020, 12(7), 1985;
Received: 29 June 2020 / Revised: 17 July 2020 / Accepted: 19 July 2020 / Published: 21 July 2020
(This article belongs to the Special Issue Medicinal Plants and Their Active Ingredients in Cancer)
In recent years, and even more since its legalization in several jurisdictions, cannabis and the endocannabinoid system have received an increasing amount of interest related to their potential exploitation in clinical settings. Cannabinoids have been suggested and shown to be effective in the treatment of various conditions. In cancer, the endocannabinoid system is altered in numerous types of tumours and can relate to cancer prognosis and disease outcome. Additionally, cannabinoids display anticancer effects in several models by suppressing the proliferation, migration and/or invasion of cancer cells, as well as tumour angiogenesis. However, the therapeutic use of cannabinoids is currently limited to the treatment of symptoms and pain associated with chemotherapy, while their potential use as cytotoxic drugs in chemotherapy still requires validation in patients. Along with cannabinoids, cannabis contains several other compounds that have also been shown to exert anti-tumorigenic actions. The potential anti-cancer effects of cannabinoids, terpenes and flavonoids, present in cannabis, are explored in this literature review. View Full-Text
Keywords: cancer; cannabis; cannabinoid; terpene; flavonoid; cytotoxicity; entourage effect cancer; cannabis; cannabinoid; terpene; flavonoid; cytotoxicity; entourage effect
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Tomko, A.M.; Whynot, E.G.; Ellis, L.D.; Dupré, D.J. Anti-Cancer Potential of Cannabinoids, Terpenes, and Flavonoids Present in Cannabis. Cancers 2020, 12, 1985.

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