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Volume 12
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Review

Hormones Secretion and Rho GTPases in Neuroendocrine Tumors

by
Laura Streit
1,
Laurent Brunaud
2,
Nicolas Vitale
1,
Stéphane Ory
1 and
Stéphane Gasman
1,*
1
Institut des Neurosciences Cellulaires et Intégratives, Centre National de la Recherche Scientifique, Université de Strasbourg, F-67000 Strasbourg, France
2
Département de Chirurgie Viscérale, Métabolique et Cancérologique (CVMC), Unité Médico-chirurgicale de Chirurgie Métabolique, Endocrinienne et Thyroïdienne (UMET), Unité Médico-chirurgicale de Chirurgie de L’obésité (UMCO), Université de Lorraine, CHRU NANCY, Hôpital Brabois Adultes, F-54511 Vandœuvre-lès-Nancy, France
*
Author to whom correspondence should be addressed.
Cancers 2020, 12(7), 1859; https://doi.org/10.3390/cancers12071859
Submission received: 5 June 2020 / Revised: 3 July 2020 / Accepted: 6 July 2020 / Published: 10 July 2020
(This article belongs to the Special Issue Rho Family of GTPases in Cancer)
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Abstract

Neuroendocrine tumors (NETs) belong to a heterogeneous group of neoplasms arising from hormone secreting cells. These tumors are often associated with a dysfunction of their secretory activity. Neuroendocrine secretion occurs through calcium-regulated exocytosis, a process that is tightly controlled by Rho GTPases family members. In this review, we compiled the numerous mutations and modification of expression levels of Rho GTPases or their regulators (Rho guanine nucleotide-exchange factors and Rho GTPase-activating proteins) that have been identified in NETs. We discussed how they might regulate neuroendocrine secretion.
Keywords: neuroendocrine tumors; Rho GTPases; hormone secretion; vesicular trafficking; mutations; expression changes neuroendocrine tumors; Rho GTPases; hormone secretion; vesicular trafficking; mutations; expression changes

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MDPI and ACS Style

Streit, L.; Brunaud, L.; Vitale, N.; Ory, S.; Gasman, S. Hormones Secretion and Rho GTPases in Neuroendocrine Tumors. Cancers 2020, 12, 1859. https://doi.org/10.3390/cancers12071859

AMA Style

Streit L, Brunaud L, Vitale N, Ory S, Gasman S. Hormones Secretion and Rho GTPases in Neuroendocrine Tumors. Cancers. 2020; 12(7):1859. https://doi.org/10.3390/cancers12071859

Chicago/Turabian Style

Streit, Laura, Laurent Brunaud, Nicolas Vitale, Stéphane Ory, and Stéphane Gasman. 2020. "Hormones Secretion and Rho GTPases in Neuroendocrine Tumors" Cancers 12, no. 7: 1859. https://doi.org/10.3390/cancers12071859

APA Style

Streit, L., Brunaud, L., Vitale, N., Ory, S., & Gasman, S. (2020). Hormones Secretion and Rho GTPases in Neuroendocrine Tumors. Cancers, 12(7), 1859. https://doi.org/10.3390/cancers12071859

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