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Open AccessArticle

Prognostic Value of CD200R1 mRNA Expression in Head and Neck Squamous Cell Carcinoma

1
Department of Medical Oncology, International St Mary’s Hospital, Catholic Kwandong University College of Medicine, Incheon 22711, Korea
2
Division of Hematology and Medical Oncology, Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul 03181, Korea
3
Division of Oncology, Department of Internal Medicine, Eunpyeong St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul 03312, Korea
4
Division of Oncology, Department of Internal Medicine, Incheon St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Incheon 21431, Korea
5
Division of Hematology and Medical Oncology, Department of Internal Medicine, Konyang University Hospital, Daejeon 35365, Korea
6
Division of Hematology/Oncology, Department of Internal Medicine, Keimyung University Dongsan Hospital, Daegu 51448, Korea
7
Division of Oncology/Hematology, Department of Internal Medicine, Korea University College of Medicine, Seoul 02841, Korea
8
Department of Internal Medicine, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam 13620, Korea
9
Division of Medical Oncology, Department of Internal Medicine, Yonsei University College of Medicine, Yonsei Cancer Center, Seoul 03722, Korea
10
Department of Internal Medicine, Seoul National University Boramae Medical Center, Seoul 07061, Korea
11
Department of Hematology-Oncology, Ajou University School of Medicine, Suwon 16499, Korea
12
Division of Hematology-Oncology, Department of Internal Medicine, Yeungnam University College of Medicine, Daegu 42415, Korea
13
Division of Hematology/Oncology, Department of Internal Medicine, Chung-Ang University Hospital, Chung-Ang University College of Medicine, Seoul 06973, Korea
14
Department of Biomedical Systems Informatics and Brain Korea 21 PLUS Project for Medical Science, Yonsei University College of Medicine, Seoul 03722, Korea
15
HERINGS, The Institute of Advanced Clinical & Biomedical Research, Seoul 08378, Korea
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Cancers 2020, 12(7), 1777; https://doi.org/10.3390/cancers12071777
Received: 16 May 2020 / Revised: 23 June 2020 / Accepted: 1 July 2020 / Published: 3 July 2020
(This article belongs to the Section Cancer Biomarkers)
Immune system dysfunction is associated with head and neck squamous cell carcinoma (HNSCC) development and progression and immune checkpoint inhibitors have demonstrated substantial survival benefits in platinum-refractory HNSCC; therefore, we examined the prognostic value of immune-related gene (IRG) expression in HNSCC. We analyzed the expression of 82 IRGs in 71 patients with HNSCC enrolled in a feasibility study for a prospective HNSCC biomarker-driven umbrella trial (Korean Cancer Study Group TRIUMPH study, NCT03292250). CD200R1 was identified as an independent prognostic factor and validated in GEO and TCGA database. CD2000R1 mRNA expression was found to be an independent favorable prognostic factor in patients with HNSCC. Moreover, CD200R1 was found to affect genes and pathways associated with the immune response, while seven differentially expressed genes (CD8A, DOK2, CX3CR1, TYROBP, CXCL9, CD300LF, IFNG) were associated with CD200R1 expression. Samples with higher CD200R1 expression displayed higher tumor-infiltrating immune cell counts both in silico and in histological analysis. These findings will help in the development of more accurate prognostic tools and suggest CD200R1 modulation as a HNSCC immunotherapy. View Full-Text
Keywords: CD2000R1; mRNA expression; prognosis; immune cell; head and neck cancer CD2000R1; mRNA expression; prognosis; immune cell; head and neck cancer
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Figure 1

MDPI and ACS Style

Chang, H.; Lee, Y.-G.; Ko, Y.H.; Cho, J.H.; Choi, J.-K.; Park, K.U.; Kang, E.J.; Lee, K.-W.; Lim, S.M.; Kim, J.-S.; Lee, H.W.; Kim, M.K.; Hwang, I.G.; Kim, S.; Nam, B.-H.; Kim, H.R. Prognostic Value of CD200R1 mRNA Expression in Head and Neck Squamous Cell Carcinoma. Cancers 2020, 12, 1777. https://doi.org/10.3390/cancers12071777

AMA Style

Chang H, Lee Y-G, Ko YH, Cho JH, Choi J-K, Park KU, Kang EJ, Lee K-W, Lim SM, Kim J-S, Lee HW, Kim MK, Hwang IG, Kim S, Nam B-H, Kim HR. Prognostic Value of CD200R1 mRNA Expression in Head and Neck Squamous Cell Carcinoma. Cancers. 2020; 12(7):1777. https://doi.org/10.3390/cancers12071777

Chicago/Turabian Style

Chang, Hyun; Lee, Yun-Gyoo; Ko, Yoon H.; Cho, Jang H.; Choi, Jong-Kwon; Park, Keon U.; Kang, Eun J.; Lee, Keun-Wook; Lim, Sun M.; Kim, Jin-Soo; Lee, Hyun W.; Kim, Min K.; Hwang, In G.; Kim, Sangwoo; Nam, Byung-Ho; Kim, Hye R. 2020. "Prognostic Value of CD200R1 mRNA Expression in Head and Neck Squamous Cell Carcinoma" Cancers 12, no. 7: 1777. https://doi.org/10.3390/cancers12071777

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