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Review

Merkel Cell Polyomavirus and Merkel Cell Carcinoma

1
Department of Public Health and Infectious Diseases, “Sapienza” University, 00185 Rome, Italy
2
IRCSS San Raffaele Pisana, Microbiology of Chronic Neuro-Degenerative Pathologies, 00166 Rome, Italy
3
Molecular Inflammation Research Group, Department of Medical Biology, Faculty of Health Sciences, University of Tromsø—The Arctic University of Norway, 9037 Tromsø, Norway
*
Author to whom correspondence should be addressed.
Cancers 2020, 12(7), 1774; https://doi.org/10.3390/cancers12071774
Received: 9 June 2020 / Revised: 26 June 2020 / Accepted: 28 June 2020 / Published: 3 July 2020
(This article belongs to the Special Issue The Biological and Clinical Aspects of Merkel Cell Carcinoma)
Viruses are the cause of approximately 15% of all human cancers. Both RNA and DNA human tumor viruses have been identified, with Merkel cell polyomavirus being the most recent one to be linked to cancer. This virus is associated with about 80% of Merkel cell carcinomas, a rare, but aggressive cutaneous malignancy. Despite its name, the cells of origin of this tumor may not be Merkel cells. This review provides an update on the structure and life cycle, cell tropism and epidemiology of the virus and its oncogenic properties. Putative strategies to prevent viral infection or treat virus-positive Merkel cell carcinoma patients are discussed. View Full-Text
Keywords: biomarkers; cell tropism; signaling pathways; therapy; transgenic mice; tumorigenesis biomarkers; cell tropism; signaling pathways; therapy; transgenic mice; tumorigenesis
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MDPI and ACS Style

Pietropaolo, V.; Prezioso, C.; Moens, U. Merkel Cell Polyomavirus and Merkel Cell Carcinoma. Cancers 2020, 12, 1774. https://doi.org/10.3390/cancers12071774

AMA Style

Pietropaolo V, Prezioso C, Moens U. Merkel Cell Polyomavirus and Merkel Cell Carcinoma. Cancers. 2020; 12(7):1774. https://doi.org/10.3390/cancers12071774

Chicago/Turabian Style

Pietropaolo, Valeria, Carla Prezioso, and Ugo Moens. 2020. "Merkel Cell Polyomavirus and Merkel Cell Carcinoma" Cancers 12, no. 7: 1774. https://doi.org/10.3390/cancers12071774

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