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Open AccessArticle

Thermal Liquid Biopsy (TLB): A Predictive Score Derived from Serum Thermograms as a Clinical Tool for Screening Lung Cancer Patients

1
Medical Oncology Department, Hospital Arnau de Vilanova, 25198 Lleida, Spain
2
Department of Statistical Methods, Universidad de Zaragoza, 50009 Zaragoza, Spain
3
Institute of Biocomputation and Physics of Complex Systems (BIFI), Joint Units IQFR-CSIC-BIFI, and GBsC-CSIC-BIFI, Universidad de Zaragoza, 50018 Zaragoza, Spain
4
Enrique Val, 50011 Zaragoza, Spain
5
Department of Medicine, University of Zaragoza, 50009 Zaragoza, Spain
6
Aragon Institute for Health Research (IIS-Aragon), 50009 Zaragoza, Spain
7
Servicio de Aparato Digestivo, Hospital Clinico Universitario Lozano Blesa, 50009 Zaragoza, Spain
8
Biomedical Research Networking Center in Digestive and Hepatic Diseases (CIBERehd), 28029 Madrid, Spain
9
Medical Oncology Department, Hospital Clinico Universitario Lozano Blesa, 50009 Zaragoza, Spain
10
Department of Biochemistry and Molecular and Cell Biology, Universidad de Zaragoza, 50009 Zaragoza, Spain
11
Fundacion ARAID, Government of Aragon, 50018 Zaragoza, Spain
12
Aragon Health Sciences Institute (IACS), 50009 Zaragoza, Spain
*
Authors to whom correspondence should be addressed.
Cancers 2019, 11(7), 1012; https://doi.org/10.3390/cancers11071012
Received: 27 May 2019 / Revised: 3 July 2019 / Accepted: 17 July 2019 / Published: 19 July 2019
(This article belongs to the Special Issue Liquid Biopsy for Cancer)
Risk population screening programs are instrumental for advancing cancer management and reducing economic costs of therapeutic interventions and the burden of the disease, as well as increasing the survival rate and improving the quality of life for cancer patients. Lung cancer, with high incidence and mortality rates, is not excluded from this situation. The success of screening programs relies on many factors, with some of them being the appropriate definition of the risk population and the implementation of detection techniques with an optimal discrimination power and strong patient adherence. Liquid biopsy based on serum or plasma detection of circulating tumor cells or DNA/RNA is increasingly employed nowadays, but certain limitations constrain its wide application. In this work, we present a new implementation of thermal liquid biopsy (TLB) for lung cancer patients. TLB provides a prediction score based on the ability to detect plasma/serum proteome alterations through calorimetric thermograms that strongly correlates with the presence of lung cancer disease (91% accuracy rate, 90% sensitivity, 92% specificity, diagnostic odds ratio 104). TLB is a quick, minimally-invasive, low-risk technique that can be applied in clinical practice for evidencing lung cancer, and it can be used in screening and monitoring actions. View Full-Text
Keywords: liquid biopsy; lung cancer; serum sample; differential scanning calorimetry; generalized linear models; cancer screening program liquid biopsy; lung cancer; serum sample; differential scanning calorimetry; generalized linear models; cancer screening program
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MDPI and ACS Style

Rodrigo, A.; Ojeda, J.L.; Vega, S.; Sanchez-Gracia, O.; Lanas, A.; Isla, D.; Velazquez-Campoy, A.; Abian, O. Thermal Liquid Biopsy (TLB): A Predictive Score Derived from Serum Thermograms as a Clinical Tool for Screening Lung Cancer Patients. Cancers 2019, 11, 1012.

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