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Three-Dimensional Calcium Alginate Hydrogel Assembly via TiOPc-Based Light-Induced Controllable Electrodeposition

Department of Mechanical and Biomedical Engineering, City University of Hong Kong, Hong Kong, China
Shenzhen Research Institute, City University of Hong Kong, Shenzhen 518057, China
Author to whom correspondence should be addressed.
Micromachines 2017, 8(6), 192;
Received: 31 March 2017 / Revised: 12 June 2017 / Accepted: 15 June 2017 / Published: 19 June 2017
(This article belongs to the Special Issue Microdevices and Microsystems for Cell Manipulation)
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Artificial reconstruction of three-dimensional (3D) hydrogel microstructures would greatly contribute to tissue assembly in vitro, and has been widely applied in tissue engineering and drug screening. Recent technological advances in the assembly of functional hydrogel microstructures such as microfluidic, 3D bioprinting, and micromold-based 3D hydrogel fabrication methods have enabled the formation of 3D tissue constructs. However, they still lack flexibility and high efficiency, which restrict their application in 3D tissue constructs. Alternatively, we report a feasible method for the fabrication and reconstruction of customized 3D hydrogel blocks. Arbitrary hydrogel microstructures were fabricated in situ via flexible and rapid light-addressable electrodeposition. To demonstrate the versatility of this method, the higher-order assembly of 3D hydrogel blocks was investigated using a constant direct current (DC) voltage (6 V) applied between two electrodes for 20–120 s. In addition to the plane-based two-dimensional (2D) assembly, hierarchical structures—including multi-layer 3D hydrogel structures and vessel-shaped structures—could be assembled using the proposed method. Overall, we developed a platform that enables researchers to construct complex 3D hydrogel microstructures efficiently and simply, which has the potential to facilitate research on drug screening and 3D tissue constructs. View Full-Text
Keywords: three-dimensional (3D) hydrogel assembly; TiOPc; alginate hydrogel; light-induced electrodeposition three-dimensional (3D) hydrogel assembly; TiOPc; alginate hydrogel; light-induced electrodeposition

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Liu, Y.; Wu, C.; Lai, H.S.S.; Liu, Y.T.; Li, W.J.; Shen, Y.J. Three-Dimensional Calcium Alginate Hydrogel Assembly via TiOPc-Based Light-Induced Controllable Electrodeposition. Micromachines 2017, 8, 192.

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