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Open AccessArticle

Pushing the Limits of Electrical Detection of Ultralow Flows in Nanofluidic Channels

MESA+ Institute for Nanotechnology, University of Twente, PO Box 217, 7500 AE Enschede, The Netherlands
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Micromachines 2013, 4(2), 138-148; https://doi.org/10.3390/mi4020138
Received: 11 December 2012 / Revised: 30 January 2013 / Accepted: 20 March 2013 / Published: 2 April 2013
This paper presents improvements in flow detection by electrical cross-correlation spectroscopy. This new technique detects molecular number fluctuations of electrochemically active analyte molecules as they are transported by liquid flow through a nanochannel. The fluctuations are used as a marker of liquid flow as their time of flight in between two consecutive transducers is determined, thereby allowing for the measurement of liquid flow rates in the picoliter-per-minute regime. Here we show an enhanced record-low sensitivity below 1 pL/min by capitalizing on improved electrical instrumentation, an optimized sensor geometry and a smaller channel cross section. We further discuss the impact of sensor geometry on the cross-correlation functions. View Full-Text
Keywords: flow detection; electrochemical sensor; nanofluidics; cross-correlation; nanochannel; redox cycling flow detection; electrochemical sensor; nanofluidics; cross-correlation; nanochannel; redox cycling
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Mathwig, K.; Lemay, S.G. Pushing the Limits of Electrical Detection of Ultralow Flows in Nanofluidic Channels. Micromachines 2013, 4, 138-148.

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