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Auranofin Inhibits the Enzyme Activity of Pasteurella multocida Toxin PMT in Human Cells and Protects Cells from Intoxication
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The Myriad Properties of Pasteurella multocida Lipopolysaccharide

Infection and Immunity Program, Monash Biomedicine Discovery Institute and Department of Microbiology, Monash University, Clayton, VIC 3800, Australia
Author to whom correspondence should be addressed.
Academic Editor: Katharina Kubatzky
Toxins 2017, 9(8), 254;
Received: 4 July 2017 / Revised: 14 August 2017 / Accepted: 15 August 2017 / Published: 21 August 2017
(This article belongs to the Special Issue Pasteurella multocida and Its Virulence Factors)
Pasteurella multocida is a heterogeneous species that is a primary pathogen of many different vertebrates. This Gram-negative bacterium can cause a range of diseases, including fowl cholera in birds, haemorrhagic septicaemia in ungulates, atrophic rhinitis in swine, and lower respiratory tract infections in cattle and pigs. One of the primary virulence factors of P. multocida is lipopolysaccharide (LPS). Recent work has shown that this crucial surface molecule shows significant structural variability across different P. multocida strains, with many producing LPS structures that are highly similar to the carbohydrate component of host glycoproteins. It is likely that this LPS mimicry of host molecules plays a major role in the survival of P. multocida in certain host niches. P. multocida LPS also plays a significant role in resisting the action of chicken cathelicidins, and is a strong stimulator of host immune responses. The inflammatory response to the endotoxic lipid A component is a major contributor to the pathogenesis of certain infections. Recent work has shown that vaccines containing killed bacteria give protection only against other strains with identical, or nearly identical, surface LPS structures. Conversely, live attenuated vaccines give protection that is broadly protective, and their efficacy is independent of LPS structure. View Full-Text
Keywords: Pasteurella multocida; lipopolysaccharide; endotoxin; immunity; virulence Pasteurella multocida; lipopolysaccharide; endotoxin; immunity; virulence
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Harper, M.; Boyce, J.D. The Myriad Properties of Pasteurella multocida Lipopolysaccharide. Toxins 2017, 9, 254.

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