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Helicobacter pylori Outer Membrane Protein-Related Pathogenesis

Department of Environmental and Preventive Medicine, Oita University Faculty of Medicine, 1-1 Idaigaoka, Hasama-Machi, Yufu-City, Oita 879-5593, Japan
Department of Medicine-Gastroenterology, Michael E. DeBakey Veterans Affairs Medical Center and Baylor College of Medicine, Houston, TX 77030, USA
Author to whom correspondence should be addressed.
Academic Editors: Jean E. Crabtree and Silja Wessler
Toxins 2017, 9(3), 101;
Received: 9 February 2017 / Revised: 8 March 2017 / Accepted: 9 March 2017 / Published: 11 March 2017
(This article belongs to the Special Issue H. pylori Virulence Factors in the Induction of Gastric Cancer)
Helicobacter pylori colonizes the human stomach and induces inflammation, and in some cases persistent infection can result in gastric cancer. Attachment to the gastric mucosa is the first step in establishing bacterial colonization, and outer membrane proteins (OMPs) play a pivotal role in binding to human cells. Some OMP interaction molecules are known in H. pylori, and their associated host cell responses have been gradually clarified. Many studies have demonstrated that OMPs are essential to CagA translocation into gastric cells via the Type IV secretion system of H. pylori. This review summarizes the mechanisms through which H. pylori utilizes OMPs to colonize the human stomach and how OMPs cooperate with the Type IV secretion system. View Full-Text
Keywords: Helicobacter pylori; outer membrane protein; pathogenesis; Type IV secretion system Helicobacter pylori; outer membrane protein; pathogenesis; Type IV secretion system
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MDPI and ACS Style

Matsuo, Y.; Kido, Y.; Yamaoka, Y. Helicobacter pylori Outer Membrane Protein-Related Pathogenesis. Toxins 2017, 9, 101.

AMA Style

Matsuo Y, Kido Y, Yamaoka Y. Helicobacter pylori Outer Membrane Protein-Related Pathogenesis. Toxins. 2017; 9(3):101.

Chicago/Turabian Style

Matsuo, Yuichi, Yasutoshi Kido, and Yoshio Yamaoka. 2017. "Helicobacter pylori Outer Membrane Protein-Related Pathogenesis" Toxins 9, no. 3: 101.

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