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Open AccessArticle

Aflatoxin B1 Detection Using a Highly-Sensitive Molecularly-Imprinted Electrochemical Sensor Based on an Electropolymerized Metal Organic Framework

1
University of Lyon, Institute of Analytical Sciences, UMR-CNRS 5280, La Doua Street, 5, Villeurbanne 69100, France
2
Key Laboratory of Pesticide and Chemical Biology of Ministry of Education, College of Chemistry, Central China Normal University, Wuhan 430079, China
3
University of Lyon, Laboratoire Hubert Curien, UMR 5516, Jean-Monnet University of Saint-Etienne, Saint-Etienne F-42023, France
*
Author to whom correspondence should be addressed.
Academic Editor: Maria C. DeRosa
Toxins 2015, 7(9), 3540-3553; https://doi.org/10.3390/toxins7093540
Received: 8 July 2015 / Revised: 10 August 2015 / Accepted: 25 August 2015 / Published: 7 September 2015
(This article belongs to the Collection Biorecognition Assays for Mycotoxins)
A sensitive electrochemical molecularly-imprinted sensor was developed for the detection of aflatoxin B1 (AFB1), by electropolymerization of p-aminothiophenol-functionalized gold nanoparticles in the presence of AFB1 as a template molecule. The extraction of the template leads to the formation of cavities that are able to specifically recognize and bind AFB1 through π-π interactions between AFB1 molecules and aniline moities. The performance of the developed sensor for the detection of AFB1 was investigated by linear sweep voltammetry using a hexacyanoferrate/hexacyanoferrite solution as a redox probe, the electron transfer rate increasing when the concentration of AFB1 increases, due to a p-doping effect. The molecularly-imprinted sensor exhibits a broad linear range, between 3.2 fM and 3.2 µM, and a quantification limit of 3 fM. Compared to the non-imprinted sensor, the imprinting factor was found to be 10. Selectivity studies were also performed towards the binding of other aflatoxins and ochratoxin A, proving good selectivity. View Full-Text
Keywords: electrochemical sensors; aflatoxin B1; molecularly imprinted polymers; metal organic framework; gold nanoparticles electrochemical sensors; aflatoxin B1; molecularly imprinted polymers; metal organic framework; gold nanoparticles
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MDPI and ACS Style

Jiang, M.; Braiek, M.; Florea, A.; Chrouda, A.; Farre, C.; Bonhomme, A.; Bessueille, F.; Vocanson, F.; Zhang, A.; Jaffrezic-Renault, N. Aflatoxin B1 Detection Using a Highly-Sensitive Molecularly-Imprinted Electrochemical Sensor Based on an Electropolymerized Metal Organic Framework. Toxins 2015, 7, 3540-3553.

AMA Style

Jiang M, Braiek M, Florea A, Chrouda A, Farre C, Bonhomme A, Bessueille F, Vocanson F, Zhang A, Jaffrezic-Renault N. Aflatoxin B1 Detection Using a Highly-Sensitive Molecularly-Imprinted Electrochemical Sensor Based on an Electropolymerized Metal Organic Framework. Toxins. 2015; 7(9):3540-3553.

Chicago/Turabian Style

Jiang, Mengjuan; Braiek, Mohamed; Florea, Anca; Chrouda, Amani; Farre, Carole; Bonhomme, Anne; Bessueille, Francois; Vocanson, Francis; Zhang, Aidong; Jaffrezic-Renault, Nicole. 2015. "Aflatoxin B1 Detection Using a Highly-Sensitive Molecularly-Imprinted Electrochemical Sensor Based on an Electropolymerized Metal Organic Framework" Toxins 7, no. 9: 3540-3553.

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