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Pain Relief in Cervical Dystonia with Botulinum Toxin Treatment

Neurology Service, Department of Medicine, Hospital Universitário, State University of Ponta Grossa, Ponta Grossa 84040-180, Brazil
Movement Disorders Unit, Neurology Service, Hospital de Clínicas, Federal University of Paraná, Curitiba 80060-900, Brazil
Author to whom correspondence should be addressed.
Academic Editor: Bahman Jabbari
Toxins 2015, 7(6), 2321-2335;
Received: 2 May 2015 / Revised: 31 May 2015 / Accepted: 15 June 2015 / Published: 23 June 2015
(This article belongs to the Collection Botulinum Toxins on Human Pain)
Dystonia is a neurological disorder characterized by intermittent or sustained muscle contractions that cause abnormal, usually repetitive, movements and postures. Dystonic movements can be tremulous and twisting and often follow a pattern. They are frequently associated with overflow muscle activation and may be triggered or worsened by voluntary action. Most voluntary muscles can be affected and, in the case of the neck muscles, the condition is referred to as cervical dystonia (CD), the most common form of dystonia. The high incidence of pain distinguishes CD from other focal dystonias and contributes significantly to patient disability and low quality of life. Different degrees of pain in the cervical region are reported by more than 60% of patients, and pain intensity is directly related to disease severity. Botulinum toxin (BoNT) is currently considered the treatment of choice for CD and can lead to an improvement in pain and dystonic symptoms in up to 90% of patients. The results for BoNT/A and BoNT/B are similar. The complex relationship between pain and dystonia has resulted in a large number of studies and more comprehensive assessments of dystonic patients. When planning the application of BoNT, pain should be a key factor in the choice of muscles and doses. In conclusion, BoNT is highly effective in controlling pain, and its analgesic effect is sustained for a long time in most CD patients. View Full-Text
Keywords: cervical dystonia; pain; treatment; botulinum toxin cervical dystonia; pain; treatment; botulinum toxin
MDPI and ACS Style

Camargo, C.H.F.; Cattai, L.; Teive, H.A.G. Pain Relief in Cervical Dystonia with Botulinum Toxin Treatment. Toxins 2015, 7, 2321-2335.

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