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Open AccessCommunication

Antivenom Cross-Neutralization of the Venoms of Hydrophis schistosus and Hydrophis curtus, Two Common Sea Snakes in Malaysian Waters

1
Department of Pharmacology, Faculty of Medicine, University of Malaya, Kuala Lumpur 50603, Malaysia
2
Department of Molecular Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur 50603, Malaysia
3
Centre for Marine & Coastal Studies (CEMACS), Universiti Sains Malaysia, Penang 11800, Malaysia
*
Author to whom correspondence should be addressed.
Academic Editor: Wolfgang Wüster
Toxins 2015, 7(2), 572-581; https://doi.org/10.3390/toxins7020572
Received: 25 November 2014 / Revised: 8 January 2015 / Accepted: 15 January 2015 / Published: 16 February 2015
(This article belongs to the Section Animal Venoms)
Sea snake envenomation is a serious occupational hazard in tropical waters. In Malaysia, the beaked sea snake (Hydrophis schistosus, formerly known as Enhydrina schistosa) and the spine-bellied sea snake (Hydrophis curtus, formerly known as Lapemis curtus or Lapemis hardwickii) are two commonly encountered species. Australian CSL sea snake antivenom is the definitive treatment for sea snake envenomation; it is unfortunately extremely costly locally and is not widely available or adequately stocked in local hospitals. This study investigated the cross-neutralizing potential of three regionally produced anti-cobra antivenoms against the venoms of Malaysian H. schistosus and H. curtus. All three antivenoms conferred paraspecific protection from sea snake venom lethality in mice, with potency increasing in the following order: Taiwan bivalent antivenom < Thai monocled cobra monovalent antivenom < Thai neuro polyvalent antivenom (NPAV). NPAV demonstrated cross-neutralizing potencies of 0.4 mg/vial for H. schistosus venom and 0.8 mg/vial for H. curtus, which translates to a dose of less than 20 vials of NPAV to neutralize an average amount of sea snake venom per bite (inferred from venom milking). The cross-neutralization activity was supported by ELISA cross-reactivity between NPAV and the venoms of H. schistosus (58.4%) and H. curtus (70.4%). These findings revealed the potential of NPAV as a second-line treatment for sea snake envenomation in the region. Further profiling of the cross-neutralization activity should address the antivenomic basis using purified toxin-based assays. View Full-Text
Keywords: sea snake; Hydrophis schistosus; Enhydrina schistosa; Hydrophis curtus; Lapemis hardwickii; antivenom; cross-neutralization; cross-reactivity sea snake; Hydrophis schistosus; Enhydrina schistosa; Hydrophis curtus; Lapemis hardwickii; antivenom; cross-neutralization; cross-reactivity
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MDPI and ACS Style

Tan, C.H.; Tan, N.H.; Tan, K.Y.; Kwong, K.O. Antivenom Cross-Neutralization of the Venoms of Hydrophis schistosus and Hydrophis curtus, Two Common Sea Snakes in Malaysian Waters. Toxins 2015, 7, 572-581. https://doi.org/10.3390/toxins7020572

AMA Style

Tan CH, Tan NH, Tan KY, Kwong KO. Antivenom Cross-Neutralization of the Venoms of Hydrophis schistosus and Hydrophis curtus, Two Common Sea Snakes in Malaysian Waters. Toxins. 2015; 7(2):572-581. https://doi.org/10.3390/toxins7020572

Chicago/Turabian Style

Tan, Choo H.; Tan, Nget H.; Tan, Kae Y.; Kwong, Kok O. 2015. "Antivenom Cross-Neutralization of the Venoms of Hydrophis schistosus and Hydrophis curtus, Two Common Sea Snakes in Malaysian Waters" Toxins 7, no. 2: 572-581. https://doi.org/10.3390/toxins7020572

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