Next Article in Journal
Toxicosis by Plant Alkaloids in Humans and Animals in Colombia
Next Article in Special Issue
Apoptosis Activation in Human Lung Cancer Cell Lines by a Novel Synthetic Peptide Derived from Conus californicus Venom
Previous Article in Journal
Highly Sensitive Colorimetric Detection of Ochratoxin A by a Label-Free Aptamer and Gold Nanoparticles
Previous Article in Special Issue
Bioactive Mimetics of Conotoxins and other Venom Peptides
Article Menu

Export Article

Open AccessReview
Toxins 2015, 7(12), 5386-5407;

Conotoxins That Could Provide Analgesia through Voltage Gated Sodium Channel Inhibition

Discipline of Pharmacology, The University of Sydney, Sydney, NSW 2006, Australia
Author to whom correspondence should be addressed.
Academic Editor: Luis Botana
Received: 14 August 2015 / Revised: 23 October 2015 / Accepted: 19 November 2015 / Published: 10 December 2015
(This article belongs to the Special Issue Conotoxins: Novel Pharmacologies for Nervous System Disorders)
Full-Text   |   PDF [539 KB, uploaded 15 December 2015]   |  


Chronic pain creates a large socio-economic burden around the world. It is physically and mentally debilitating, and many suffers are unresponsive to current therapeutics. Many drugs that provide pain relief have adverse side effects and addiction liabilities. Therefore, a great need has risen for alternative treatment strategies. One rich source of potential analgesic compounds that has immerged over the past few decades are conotoxins. These toxins are extremely diverse and display selective activity at ion channels. Voltage gated sodium (NaV) channels are one such group of ion channels that play a significant role in multiple pain pathways. This review will explore the literature around conotoxins that bind NaV channels and determine their analgesic potential. View Full-Text
Keywords: conotoxins; toxins; NaV; ion channels; pain; analgesia; inhibition conotoxins; toxins; NaV; ion channels; pain; analgesia; inhibition

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

Share & Cite This Article

MDPI and ACS Style

Munasinghe, N.R.; Christie, M.J. Conotoxins That Could Provide Analgesia through Voltage Gated Sodium Channel Inhibition. Toxins 2015, 7, 5386-5407.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Toxins EISSN 2072-6651 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top