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Open AccessArticle

EDIN-B Promotes the Translocation of Staphylococcus aureus to the Bloodstream in the Course of Pneumonia

1
INSERM U1065, Equipe Labellisée Ligue Contre le Cancer, Centre Méditerranéen de Médecine Moléculaire (C3M), Université de Nice Sophia-Antipolis, Nice 06204, France
2
CIRI, International Center for Infectiology Research, Inserm U1111, Université Lyon 1, Ecole Normale Supérieure de Lyon, CNRS UMR5308, 7 Rue Guillaume Paradin, Lyon 69372, France
3
CNRS UMR 7278, IRD198, INSERM U1095, Aix-Marseille Université, 27 Bd Jean Moulin, Marseille 13385, France
4
Service de Microbiologie, CHU Carémeau, Place du Professeur Robert Debré, Nîmes 30029, France
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Academic Editor: Yinduo Ji
Toxins 2015, 7(10), 4131-4142; https://doi.org/10.3390/toxins7104131
Received: 18 August 2015 / Revised: 25 September 2015 / Accepted: 30 September 2015 / Published: 15 October 2015
(This article belongs to the Collection Staphylococcus aureus Toxins)
It is crucial to define risk factors that contribute to host invasion by Staphylococcus aureus. Here, we demonstrate that the chromosomally encoded EDIN-B isoform from S. aureus contributes to the onset of bacteremia during the course of pneumonia. Deletion of edinB in a European lineage community-acquired methicillin resistant S. aureus (CA-MRSA) strain (ST80-MRSA-IV) dramatically decreased the frequency and magnitude of bacteremia in mice suffering from pneumonia. This deletion had no effect on the bacterial burden in both blood circulation and lung tissues. Re-expression of wild-type EDIN-B, unlike the catalytically inactive mutant EDIN-R185E, restored the invasive characteristics of ST80-MRSA-IV. View Full-Text
Keywords: bacteremia; virulence factor; toxins; methicillin-resistant Staphylococcus aureus bacteremia; virulence factor; toxins; methicillin-resistant Staphylococcus aureus
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Courjon, J.; Munro, P.; Benito, Y.; Visvikis, O.; Bouchiat, C.; Boyer, L.; Doye, A.; Lepidi, H.; Ghigo, E.; Lavigne, J.-P.; Vandenesch, F.; Lemichez, E. EDIN-B Promotes the Translocation of Staphylococcus aureus to the Bloodstream in the Course of Pneumonia. Toxins 2015, 7, 4131-4142.

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