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Deficient Glutathione in the Pathophysiology of Mycotoxin-Related Illness

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Toxins 2014, 6(2), 608-623; https://doi.org/10.3390/toxins6020608
Received: 30 October 2013 / Revised: 21 January 2014 / Accepted: 23 January 2014 / Published: 10 February 2014
(This article belongs to the Special Issue Mycotoxins and Human Diseases)
Evidence for the role of oxidative stress in the pathophysiology of mycotoxin-related illness is increasing. The glutathione antioxidant and detoxification systems play a major role in the antioxidant function of cells. Exposure to mycotoxins in humans requires the production of glutathione on an “as needed” basis. Research suggests that mycotoxins can decrease the formation of glutathione due to decreased gene expression of the enzymes needed to form glutathione. Mycotoxin-related compromise of glutathione production can result in an excess of oxidative stress that leads to tissue damage and systemic illness. The review discusses the mechanisms by which mycotoxin-related deficiency of glutathione may lead to both acute and chronic illnesses. View Full-Text
Keywords: glutathione; mycotoxin; aflatoxin; ochratoxin; trichothecene; Nrf2 modification; genetic polymorphism; oxidative stress glutathione; mycotoxin; aflatoxin; ochratoxin; trichothecene; Nrf2 modification; genetic polymorphism; oxidative stress
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Guilford, F.T.; Hope, J. Deficient Glutathione in the Pathophysiology of Mycotoxin-Related Illness. Toxins 2014, 6, 608-623.

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