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Consequences and Utility of the Zinc-Dependent Metalloprotease Activity of Anthrax Lethal Toxin

1
Laboratory of Cancer and Developmental Cell Biology, The Van Andel Research Institute, 333 Bostwick NE Grand Rapids, MI, 49503, USA
2
Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing MI 48824, USA
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Author to whom correspondence should be addressed.
Toxins 2010, 2(5), 1038-1053; https://doi.org/10.3390/toxins2051038
Received: 2 April 2010 / Revised: 29 April 2010 / Accepted: 5 May 2010 / Published: 11 May 2010
(This article belongs to the Special Issue Protein Toxins as Proteases)
Anthrax is caused by the gram-positive bacterium Bacillus anthracis. The pathogenesis of this disease is dependent on the presence of two binary toxins, edema toxin (EdTx) and lethal toxin (LeTx). LeTx, the major virulence factor contributing to anthrax, contains the effector moiety lethal factor (LF), a zinc-dependent metalloprotease specific for targeting mitogen-activated protein kinase kinases. This review will focus on the protease-specific activity and function of LF, and will include a discussion on the implications and consequences of this activity, both in terms of anthrax disease, and how this activity can be exploited to gain insight into other pathologic conditions. View Full-Text
Keywords: anthrax; lethal factor; mitogen-activated protein kinase kinase; pathogenesis; metalloprotease; tumorigenesis; retinal neovascularization anthrax; lethal factor; mitogen-activated protein kinase kinase; pathogenesis; metalloprotease; tumorigenesis; retinal neovascularization
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Bromberg-White, J.; Lee, C.-S.; Duesbery, N. Consequences and Utility of the Zinc-Dependent Metalloprotease Activity of Anthrax Lethal Toxin. Toxins 2010, 2, 1038-1053.

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