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Toxins–Useful Biochemical Tools for Leukocyte Research

Department of Dermatology, Medical School Jena, Erfurter Strasse 35, 07740, Jena, Germany
Author to whom correspondence should be addressed.
Toxins 2010, 2(4), 428-452;
Received: 8 March 2010 / Accepted: 24 March 2010 / Published: 26 March 2010
(This article belongs to the Collection Toxicity and Therapeutic Interventions in the Immune System)
Leukocytes are a heterogeneous group of cells that display differences in anatomic localization, cell surface phenotype, and function. The different subtypes include e.g., granulocytes, monocytes, dendritic cells, T cells, B cells and NK cells. These different cell types represent the cellular component of innate and adaptive immunity. Using certain toxins such as pertussis toxin, cholera toxin or clostridium difficile toxin, the regulatory functions of Gαi, Gαs and small GTPases of the Rho family in leukocytes have been reported. A summary of these reports is discussed in this review. View Full-Text
Keywords: toxins; leukocytes; signal transduction toxins; leukocytes; signal transduction
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MDPI and ACS Style

Cubillos, S.; Norgauer, J.; Lehmann, K. Toxins–Useful Biochemical Tools for Leukocyte Research. Toxins 2010, 2, 428-452.

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